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Microtubule instability driven by longitudinal and lateral strain propagation

Tubulin dimers associate longitudinally and laterally to form metastable microtubules (MTs). MT disassembly is preceded by subtle structural changes in tubulin fueled by GTP hydrolysis. These changes render the MT lattice unstable, but it is unclear exactly how they affect lattice energetics and str...

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Detalles Bibliográficos
Autores principales: Igaev, Maxim, Grubmüller, Helmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467311/
https://www.ncbi.nlm.nih.gov/pubmed/32877399
http://dx.doi.org/10.1371/journal.pcbi.1008132