Electric Field Measurements Reveal the Pivotal Role of Cofactor–Substrate Interaction in Dihydrofolate Reductase Catalysis

[Image: see text] The contribution of ligand–ligand electrostatic interaction to transition state formation during enzyme catalysis has remained unexplored, even though electrostatic forces are known to play a major role in protein functions and have been investigated by the vibrational Stark effect...

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Detalles Bibliográficos
Autores principales: Adesina, Aduragbemi S., Świderek, Katarzyna, Luk, Louis Y. P., Moliner, Vicent, Allemann, Rudolf K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467645/
https://www.ncbi.nlm.nih.gov/pubmed/32905264
http://dx.doi.org/10.1021/acscatal.0c01856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467645/
https://www.ncbi.nlm.nih.gov/pubmed/32905264
http://dx.doi.org/10.1021/acscatal.0c01856

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