Meiotic chromosome synapsis depends on multivalent SYCE1-SIX6OS1 interactions that are disrupted in cases of human infertility

Meiotic reductional division depends on the synaptonemal complex (SC), a supramolecular protein assembly that mediates homologous chromosomes synapsis and promotes crossover formation. The mammalian SC has eight structural components, including SYCE1, the only central element protein with known caus...

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Detalles Bibliográficos
Autores principales: Sánchez-Sáez, Fernando, Gómez-H, Laura, Dunne, Orla M., Gallego-Páramo, Cristina, Felipe-Medina, Natalia, Sánchez-Martín, Manuel, Llano, Elena, Pendas, Alberto M., Davies, Owen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467691/
https://www.ncbi.nlm.nih.gov/pubmed/32917591
http://dx.doi.org/10.1126/sciadv.abb1660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467691/
https://www.ncbi.nlm.nih.gov/pubmed/32917591
http://dx.doi.org/10.1126/sciadv.abb1660

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