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Parabrachial neuron types categorically encode thermoregulation variables during heat defense

Heat defense is crucial for survival and fitness. Transmission of thermosensory signals into hypothalamic thermoregulation centers represents a key layer of regulation in heat defense. Yet, how these signals are transmitted into the hypothalamus remains poorly understood. Here, we reveal that latera...

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Autores principales: Yang, Wen Z., Du, Xiaosa, Zhang, Wen, Gao, Cuicui, Xie, Hengchang, Xiao, Yan, Jia, Xiaoning, Liu, Jiashu, Xu, Jianhui, Fu, Xin, Tu, Hongqing, Fu, Xiaoyu, Ni, Xinyan, He, Miao, Yang, Jiajun, Wang, Hong, Yang, Haitao, Xu, Xiao-hong, Shen, Wei L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467693/
https://www.ncbi.nlm.nih.gov/pubmed/32917598
http://dx.doi.org/10.1126/sciadv.abb9414
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author Yang, Wen Z.
Du, Xiaosa
Zhang, Wen
Gao, Cuicui
Xie, Hengchang
Xiao, Yan
Jia, Xiaoning
Liu, Jiashu
Xu, Jianhui
Fu, Xin
Tu, Hongqing
Fu, Xiaoyu
Ni, Xinyan
He, Miao
Yang, Jiajun
Wang, Hong
Yang, Haitao
Xu, Xiao-hong
Shen, Wei L.
author_facet Yang, Wen Z.
Du, Xiaosa
Zhang, Wen
Gao, Cuicui
Xie, Hengchang
Xiao, Yan
Jia, Xiaoning
Liu, Jiashu
Xu, Jianhui
Fu, Xin
Tu, Hongqing
Fu, Xiaoyu
Ni, Xinyan
He, Miao
Yang, Jiajun
Wang, Hong
Yang, Haitao
Xu, Xiao-hong
Shen, Wei L.
author_sort Yang, Wen Z.
collection PubMed
description Heat defense is crucial for survival and fitness. Transmission of thermosensory signals into hypothalamic thermoregulation centers represents a key layer of regulation in heat defense. Yet, how these signals are transmitted into the hypothalamus remains poorly understood. Here, we reveal that lateral parabrachial nucleus (LPB) glutamatergic prodynorphin and cholecystokinin neuron populations are progressively recruited to defend elevated body temperature. These two nonoverlapping neuron types form circuits with downstream preoptic hypothalamic neurons to inhibit the thermogenesis of brown adipose tissues (BATs) and activate tail vasodilation, respectively. Both circuits are activated by warmth and can limit fever development. The prodynorphin circuit is further required for regulating energy expenditure and body weight homeostasis. Thus, these findings establish that the genetic and functional specificity of heat defense neurons occurs as early as in the LPB and uncover categorical neuron types for encoding two heat defense variables, inhibition of BAT thermogenesis and activation of vasodilation.
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spelling pubmed-74676932020-09-17 Parabrachial neuron types categorically encode thermoregulation variables during heat defense Yang, Wen Z. Du, Xiaosa Zhang, Wen Gao, Cuicui Xie, Hengchang Xiao, Yan Jia, Xiaoning Liu, Jiashu Xu, Jianhui Fu, Xin Tu, Hongqing Fu, Xiaoyu Ni, Xinyan He, Miao Yang, Jiajun Wang, Hong Yang, Haitao Xu, Xiao-hong Shen, Wei L. Sci Adv Research Articles Heat defense is crucial for survival and fitness. Transmission of thermosensory signals into hypothalamic thermoregulation centers represents a key layer of regulation in heat defense. Yet, how these signals are transmitted into the hypothalamus remains poorly understood. Here, we reveal that lateral parabrachial nucleus (LPB) glutamatergic prodynorphin and cholecystokinin neuron populations are progressively recruited to defend elevated body temperature. These two nonoverlapping neuron types form circuits with downstream preoptic hypothalamic neurons to inhibit the thermogenesis of brown adipose tissues (BATs) and activate tail vasodilation, respectively. Both circuits are activated by warmth and can limit fever development. The prodynorphin circuit is further required for regulating energy expenditure and body weight homeostasis. Thus, these findings establish that the genetic and functional specificity of heat defense neurons occurs as early as in the LPB and uncover categorical neuron types for encoding two heat defense variables, inhibition of BAT thermogenesis and activation of vasodilation. American Association for the Advancement of Science 2020-09-02 /pmc/articles/PMC7467693/ /pubmed/32917598 http://dx.doi.org/10.1126/sciadv.abb9414 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Yang, Wen Z.
Du, Xiaosa
Zhang, Wen
Gao, Cuicui
Xie, Hengchang
Xiao, Yan
Jia, Xiaoning
Liu, Jiashu
Xu, Jianhui
Fu, Xin
Tu, Hongqing
Fu, Xiaoyu
Ni, Xinyan
He, Miao
Yang, Jiajun
Wang, Hong
Yang, Haitao
Xu, Xiao-hong
Shen, Wei L.
Parabrachial neuron types categorically encode thermoregulation variables during heat defense
title Parabrachial neuron types categorically encode thermoregulation variables during heat defense
title_full Parabrachial neuron types categorically encode thermoregulation variables during heat defense
title_fullStr Parabrachial neuron types categorically encode thermoregulation variables during heat defense
title_full_unstemmed Parabrachial neuron types categorically encode thermoregulation variables during heat defense
title_short Parabrachial neuron types categorically encode thermoregulation variables during heat defense
title_sort parabrachial neuron types categorically encode thermoregulation variables during heat defense
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467693/
https://www.ncbi.nlm.nih.gov/pubmed/32917598
http://dx.doi.org/10.1126/sciadv.abb9414
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