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Parabrachial neuron types categorically encode thermoregulation variables during heat defense
Heat defense is crucial for survival and fitness. Transmission of thermosensory signals into hypothalamic thermoregulation centers represents a key layer of regulation in heat defense. Yet, how these signals are transmitted into the hypothalamus remains poorly understood. Here, we reveal that latera...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467693/ https://www.ncbi.nlm.nih.gov/pubmed/32917598 http://dx.doi.org/10.1126/sciadv.abb9414 |
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author | Yang, Wen Z. Du, Xiaosa Zhang, Wen Gao, Cuicui Xie, Hengchang Xiao, Yan Jia, Xiaoning Liu, Jiashu Xu, Jianhui Fu, Xin Tu, Hongqing Fu, Xiaoyu Ni, Xinyan He, Miao Yang, Jiajun Wang, Hong Yang, Haitao Xu, Xiao-hong Shen, Wei L. |
author_facet | Yang, Wen Z. Du, Xiaosa Zhang, Wen Gao, Cuicui Xie, Hengchang Xiao, Yan Jia, Xiaoning Liu, Jiashu Xu, Jianhui Fu, Xin Tu, Hongqing Fu, Xiaoyu Ni, Xinyan He, Miao Yang, Jiajun Wang, Hong Yang, Haitao Xu, Xiao-hong Shen, Wei L. |
author_sort | Yang, Wen Z. |
collection | PubMed |
description | Heat defense is crucial for survival and fitness. Transmission of thermosensory signals into hypothalamic thermoregulation centers represents a key layer of regulation in heat defense. Yet, how these signals are transmitted into the hypothalamus remains poorly understood. Here, we reveal that lateral parabrachial nucleus (LPB) glutamatergic prodynorphin and cholecystokinin neuron populations are progressively recruited to defend elevated body temperature. These two nonoverlapping neuron types form circuits with downstream preoptic hypothalamic neurons to inhibit the thermogenesis of brown adipose tissues (BATs) and activate tail vasodilation, respectively. Both circuits are activated by warmth and can limit fever development. The prodynorphin circuit is further required for regulating energy expenditure and body weight homeostasis. Thus, these findings establish that the genetic and functional specificity of heat defense neurons occurs as early as in the LPB and uncover categorical neuron types for encoding two heat defense variables, inhibition of BAT thermogenesis and activation of vasodilation. |
format | Online Article Text |
id | pubmed-7467693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-74676932020-09-17 Parabrachial neuron types categorically encode thermoregulation variables during heat defense Yang, Wen Z. Du, Xiaosa Zhang, Wen Gao, Cuicui Xie, Hengchang Xiao, Yan Jia, Xiaoning Liu, Jiashu Xu, Jianhui Fu, Xin Tu, Hongqing Fu, Xiaoyu Ni, Xinyan He, Miao Yang, Jiajun Wang, Hong Yang, Haitao Xu, Xiao-hong Shen, Wei L. Sci Adv Research Articles Heat defense is crucial for survival and fitness. Transmission of thermosensory signals into hypothalamic thermoregulation centers represents a key layer of regulation in heat defense. Yet, how these signals are transmitted into the hypothalamus remains poorly understood. Here, we reveal that lateral parabrachial nucleus (LPB) glutamatergic prodynorphin and cholecystokinin neuron populations are progressively recruited to defend elevated body temperature. These two nonoverlapping neuron types form circuits with downstream preoptic hypothalamic neurons to inhibit the thermogenesis of brown adipose tissues (BATs) and activate tail vasodilation, respectively. Both circuits are activated by warmth and can limit fever development. The prodynorphin circuit is further required for regulating energy expenditure and body weight homeostasis. Thus, these findings establish that the genetic and functional specificity of heat defense neurons occurs as early as in the LPB and uncover categorical neuron types for encoding two heat defense variables, inhibition of BAT thermogenesis and activation of vasodilation. American Association for the Advancement of Science 2020-09-02 /pmc/articles/PMC7467693/ /pubmed/32917598 http://dx.doi.org/10.1126/sciadv.abb9414 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Yang, Wen Z. Du, Xiaosa Zhang, Wen Gao, Cuicui Xie, Hengchang Xiao, Yan Jia, Xiaoning Liu, Jiashu Xu, Jianhui Fu, Xin Tu, Hongqing Fu, Xiaoyu Ni, Xinyan He, Miao Yang, Jiajun Wang, Hong Yang, Haitao Xu, Xiao-hong Shen, Wei L. Parabrachial neuron types categorically encode thermoregulation variables during heat defense |
title | Parabrachial neuron types categorically encode thermoregulation variables during heat defense |
title_full | Parabrachial neuron types categorically encode thermoregulation variables during heat defense |
title_fullStr | Parabrachial neuron types categorically encode thermoregulation variables during heat defense |
title_full_unstemmed | Parabrachial neuron types categorically encode thermoregulation variables during heat defense |
title_short | Parabrachial neuron types categorically encode thermoregulation variables during heat defense |
title_sort | parabrachial neuron types categorically encode thermoregulation variables during heat defense |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467693/ https://www.ncbi.nlm.nih.gov/pubmed/32917598 http://dx.doi.org/10.1126/sciadv.abb9414 |
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