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Structural Determinants of Insulin Release: Disordered N-Terminal Tail of Kir6.2 Affects Potassium Channel Dynamics through Interactions with Sulfonylurea Binding Region in a SUR1 Partner

[Image: see text] Inward rectifying potassium ion channels (KATP), sensitive to the ATP/ADP concentration ratio, play an important, control role in pancreatic β cells. The channels close upon the increase of this ratio, which, in turn, triggers insulin release to blood. Numerous mutations in KATP le...

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Detalles Bibliográficos
Autores principales: Walczewska-Szewc, Katarzyna, Nowak, Wiesław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467719/
https://www.ncbi.nlm.nih.gov/pubmed/32598150
http://dx.doi.org/10.1021/acs.jpcb.0c02720