Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly

Holoprosencephaly (HPE), a defect in midline patterning of the forebrain and midface, arises ~1 in 250 conceptions. It is associated with predisposing mutations in the Nodal and Hedgehog (HH) pathways, with penetrance and expressivity graded by genetic and environmental modifiers, via poorly underst...

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Detalles Bibliográficos
Autores principales: Hong, Mingi, Christ, Annabel, Christa, Anna, Willnow, Thomas E, Krauss, Robert S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467722/
https://www.ncbi.nlm.nih.gov/pubmed/32876567
http://dx.doi.org/10.7554/eLife.60351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467722/
https://www.ncbi.nlm.nih.gov/pubmed/32876567
http://dx.doi.org/10.7554/eLife.60351

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