Cargando…
Cdon mutation and fetal alcohol converge on Nodal signaling in a mouse model of holoprosencephaly
Holoprosencephaly (HPE), a defect in midline patterning of the forebrain and midface, arises ~1 in 250 conceptions. It is associated with predisposing mutations in the Nodal and Hedgehog (HH) pathways, with penetrance and expressivity graded by genetic and environmental modifiers, via poorly underst...
Autores principales: | Hong, Mingi, Christ, Annabel, Christa, Anna, Willnow, Thomas E, Krauss, Robert S |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467722/ https://www.ncbi.nlm.nih.gov/pubmed/32876567 http://dx.doi.org/10.7554/eLife.60351 |
Ejemplares similares
-
Rescue of Holoprosencephaly in Fetal Alcohol-Exposed Cdon Mutant Mice by Reduced Gene Dosage of Ptch1
por: Hong, Mingi, et al.
Publicado: (2013) -
Cdon Mutation and Fetal Ethanol Exposure Synergize to Produce Midline Signaling Defects and Holoprosencephaly Spectrum Disorders in Mice
por: Hong, Mingi, et al.
Publicado: (2012) -
Concepts in Multifactorial Etiology of Developmental Disorders: Gene-Gene and Gene-Environment Interactions in Holoprosencephaly
por: Lo, Hsiao-Fan, et al.
Publicado: (2021) -
Ethanol itself is a holoprosencephaly-inducing teratogen
por: Hong, Mingi, et al.
Publicado: (2017) -
Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia
por: Kahn, Benjamin M., et al.
Publicado: (2017)