CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance

Porcine reproductive and respiratory syndrome virus (PRRSV) and transmissible gastroenteritis virus (TGEV) are two highly infectious and lethal viruses causing major economic losses to pig production. Here, we report generation of double-gene-knockout (DKO) pigs harboring edited knockout alleles for...

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Detalles Bibliográficos
Autores principales: Xu, Kui, Zhou, Yanrong, Mu, Yulian, Liu, Zhiguo, Hou, Shaohua, Xiong, Yujian, Fang, Liurong, Ge, Changli, Wei, Yinghui, Zhang, Xiuling, Xu, Changjiang, Che, Jingjing, Fan, Ziyao, Xiang, Guangming, Guo, Jiankang, Shang, Haitao, Li, Hua, Xiao, Shaobo, Li, Julang, Li, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467724/
https://www.ncbi.nlm.nih.gov/pubmed/32876563
http://dx.doi.org/10.7554/eLife.57132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467724/
https://www.ncbi.nlm.nih.gov/pubmed/32876563
http://dx.doi.org/10.7554/eLife.57132

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