The dynamic nature of the human origin recognition complex revealed through five cryoEM structures

Genome replication is initiated from specific origin sites established by dynamic events. The Origin Recognition Complex (ORC) is necessary for orchestrating the initiation process by binding to origin DNA, recruiting CDC6, and assembling the MCM replicative helicase on DNA. Here we report five cryo...

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Detalles Bibliográficos
Autores principales: Jaremko, Matt J, On, Kin Fan, Thomas, Dennis R, Stillman, Bruce, Joshua-Tor, Leemor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467728/
https://www.ncbi.nlm.nih.gov/pubmed/32808929
http://dx.doi.org/10.7554/eLife.58622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467728/
https://www.ncbi.nlm.nih.gov/pubmed/32808929
http://dx.doi.org/10.7554/eLife.58622

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