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Mechanisms underlying genome instability mediated by formation of foldback inversions in Saccharomyces cerevisiae

Foldback inversions, also called inverted duplications, have been observed in human genetic diseases and cancers. Here, we used a Saccharomyces cerevisiae genetic system that generates gross chromosomal rearrangements (GCRs) mediated by foldback inversions combined with whole-genome sequencing to st...

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Detalles Bibliográficos
Autores principales: Li, Bin-zhong, Putnam, Christopher D, Kolodner, Richard David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467729/
https://www.ncbi.nlm.nih.gov/pubmed/32762846
http://dx.doi.org/10.7554/eLife.58223