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The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA)
[Image: see text] The resolution of inflammation is governed by the active biosynthesis of specialized pro-resolving mediators using ω-6 and ω-3 polyunsaturated fatty acids as substrates. These mediators act as resolution agonists and display several interesting bioactivities. PD2(n-3 DPA) is an oxy...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society and American
Society of Pharmacognosy
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467816/ https://www.ncbi.nlm.nih.gov/pubmed/32543839 http://dx.doi.org/10.1021/acs.jnatprod.0c00385 |
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author | Tungen, Jørn Eivind Primdahl, Karoline Gangestad Hansen, Trond Vidar |
author_facet | Tungen, Jørn Eivind Primdahl, Karoline Gangestad Hansen, Trond Vidar |
author_sort | Tungen, Jørn Eivind |
collection | PubMed |
description | [Image: see text] The resolution of inflammation is governed by the active biosynthesis of specialized pro-resolving mediators using ω-6 and ω-3 polyunsaturated fatty acids as substrates. These mediators act as resolution agonists and display several interesting bioactivities. PD2(n-3 DPA) is an oxygenated polyunsaturated fatty acid biosynthesized from n-3 docosapentaenoic acid belonging to the specialized pro-resolving lipid mediator family named protectins. The protectins exhibit anti-inflammatory properties and pro-resolving bioactivities. These endogenously produced compounds are of interest as leads in resolution pharmacology and drug development. Herein, together with its NMR, MS, and UV data, a stereoselective total synthesis of PD2(n-3 DPA) is presented. |
format | Online Article Text |
id | pubmed-7467816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Chemical
Society and American
Society of Pharmacognosy |
record_format | MEDLINE/PubMed |
spelling | pubmed-74678162020-09-03 The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA) Tungen, Jørn Eivind Primdahl, Karoline Gangestad Hansen, Trond Vidar J Nat Prod [Image: see text] The resolution of inflammation is governed by the active biosynthesis of specialized pro-resolving mediators using ω-6 and ω-3 polyunsaturated fatty acids as substrates. These mediators act as resolution agonists and display several interesting bioactivities. PD2(n-3 DPA) is an oxygenated polyunsaturated fatty acid biosynthesized from n-3 docosapentaenoic acid belonging to the specialized pro-resolving lipid mediator family named protectins. The protectins exhibit anti-inflammatory properties and pro-resolving bioactivities. These endogenously produced compounds are of interest as leads in resolution pharmacology and drug development. Herein, together with its NMR, MS, and UV data, a stereoselective total synthesis of PD2(n-3 DPA) is presented. American Chemical Society and American Society of Pharmacognosy 2020-06-16 2020-07-24 /pmc/articles/PMC7467816/ /pubmed/32543839 http://dx.doi.org/10.1021/acs.jnatprod.0c00385 Text en Copyright © 2020 American Chemical Society and American Society of Pharmacognosy This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
spellingShingle | Tungen, Jørn Eivind Primdahl, Karoline Gangestad Hansen, Trond Vidar The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA) |
title | The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA) |
title_full | The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA) |
title_fullStr | The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA) |
title_full_unstemmed | The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA) |
title_short | The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA) |
title_sort | first total synthesis of the lipid mediator pd2(n-3 dpa) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467816/ https://www.ncbi.nlm.nih.gov/pubmed/32543839 http://dx.doi.org/10.1021/acs.jnatprod.0c00385 |
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