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The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA)

[Image: see text] The resolution of inflammation is governed by the active biosynthesis of specialized pro-resolving mediators using ω-6 and ω-3 polyunsaturated fatty acids as substrates. These mediators act as resolution agonists and display several interesting bioactivities. PD2(n-3 DPA) is an oxy...

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Autores principales: Tungen, Jørn Eivind, Primdahl, Karoline Gangestad, Hansen, Trond Vidar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467816/
https://www.ncbi.nlm.nih.gov/pubmed/32543839
http://dx.doi.org/10.1021/acs.jnatprod.0c00385
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author Tungen, Jørn Eivind
Primdahl, Karoline Gangestad
Hansen, Trond Vidar
author_facet Tungen, Jørn Eivind
Primdahl, Karoline Gangestad
Hansen, Trond Vidar
author_sort Tungen, Jørn Eivind
collection PubMed
description [Image: see text] The resolution of inflammation is governed by the active biosynthesis of specialized pro-resolving mediators using ω-6 and ω-3 polyunsaturated fatty acids as substrates. These mediators act as resolution agonists and display several interesting bioactivities. PD2(n-3 DPA) is an oxygenated polyunsaturated fatty acid biosynthesized from n-3 docosapentaenoic acid belonging to the specialized pro-resolving lipid mediator family named protectins. The protectins exhibit anti-inflammatory properties and pro-resolving bioactivities. These endogenously produced compounds are of interest as leads in resolution pharmacology and drug development. Herein, together with its NMR, MS, and UV data, a stereoselective total synthesis of PD2(n-3 DPA) is presented.
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spelling pubmed-74678162020-09-03 The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA) Tungen, Jørn Eivind Primdahl, Karoline Gangestad Hansen, Trond Vidar J Nat Prod [Image: see text] The resolution of inflammation is governed by the active biosynthesis of specialized pro-resolving mediators using ω-6 and ω-3 polyunsaturated fatty acids as substrates. These mediators act as resolution agonists and display several interesting bioactivities. PD2(n-3 DPA) is an oxygenated polyunsaturated fatty acid biosynthesized from n-3 docosapentaenoic acid belonging to the specialized pro-resolving lipid mediator family named protectins. The protectins exhibit anti-inflammatory properties and pro-resolving bioactivities. These endogenously produced compounds are of interest as leads in resolution pharmacology and drug development. Herein, together with its NMR, MS, and UV data, a stereoselective total synthesis of PD2(n-3 DPA) is presented. American Chemical Society and American Society of Pharmacognosy 2020-06-16 2020-07-24 /pmc/articles/PMC7467816/ /pubmed/32543839 http://dx.doi.org/10.1021/acs.jnatprod.0c00385 Text en Copyright © 2020 American Chemical Society and American Society of Pharmacognosy This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Tungen, Jørn Eivind
Primdahl, Karoline Gangestad
Hansen, Trond Vidar
The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA)
title The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA)
title_full The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA)
title_fullStr The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA)
title_full_unstemmed The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA)
title_short The First Total Synthesis of the Lipid Mediator PD2(n-3 DPA)
title_sort first total synthesis of the lipid mediator pd2(n-3 dpa)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467816/
https://www.ncbi.nlm.nih.gov/pubmed/32543839
http://dx.doi.org/10.1021/acs.jnatprod.0c00385
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