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Data-driven analysis of a mechanistic model of CAR T cell signaling predicts effects of cell-to-cell heterogeneity

Due to the variability of protein expression, cells of the same population can exhibit different responses to stimuli. It is important to understand this heterogeneity at the individual level, as population averages mask these underlying differences. Using computational modeling, we can interrogate...

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Detalles Bibliográficos
Autores principales: Cess, Colin G., Finley, Stacey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467855/
https://www.ncbi.nlm.nih.gov/pubmed/31866395
http://dx.doi.org/10.1016/j.jtbi.2019.110125