Cargando…

PLCɛ maintains the functionality of AR signaling in prostate cancer via an autophagy-dependent mechanism

Androgen receptor (AR) signaling is a major driver of prostate cancer (CaP). Although most therapies targeting AR are initially effective in CaP patients, drug resistance is inevitable, mainly because of the inappropriate re-activation of AR pathway. However, the underlying mechanisms remain largely...

Descripción completa

Detalles Bibliográficos
Autores principales:	Quan, Zhen, Li, Ting, Xia, Yang, Liu, Jiayu, Du, Zhongbo, Luo, Chunli, He, Yunfeng, Wu, Xiaohou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468107/ https://www.ncbi.nlm.nih.gov/pubmed/32879302 http://dx.doi.org/10.1038/s41419-020-02917-9

Ejemplares similares

Knockdown of Phospholipase Cɛ (PLCɛ) Inhibits Cell Proliferation via Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN)/AKT Signaling Pathway in Human Prostate Cancer
por: Wang, Xiao, et al.
Publicado: (2018)

PLCε knockdown enhances the radiosensitivity of castration-resistant prostate cancer via the AR/PARP1/DNA-PKcs axis
por: Pu, Jun, et al.
Publicado: (2020)

PLCε knockdown enhances the radiosensitivity of castration-resistant prostate cancer via the AR/PARP1/DNA-PKcs axis
por: Pu, Jun, et al.
Publicado: (2022)

HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain
por: Deng, Qingfu, et al.
Publicado: (2019)

HepaCAM inhibits cell proliferation and invasion in prostate cancer by suppressing nuclear translocation of the androgen receptor via its cytoplasmic domain
por: Deng, Qingfu, et al.
Publicado: (2022)

Phospholipase C (PLC)ɛ Promotes Androgen Receptor Antagonist Resistance via the Bone Morphogenetic Protein (BMP)-6/SMAD Axis in a Castration-Resistant Prostate Cancer Cell Line
por: Yuan, Mengjuan, et al.
Publicado: (2019)

Combination of phospholipase Cε knockdown with GANT61 sensitizes castration-resistant prostate cancer cells to enzalutamide by suppressing the androgen receptor signaling pathway
por: Sun, Wei, et al.
Publicado: (2019)

Combination of phospholipase Cε knockdown with GANT61 sensitizes castration-resistant prostate cancer cells to enzalutamide by suppressing the androgen receptor signaling pathway
por: Sun, Wei, et al.
Publicado: (2022)

PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail()
por: Zhai, Shicong, et al.
Publicado: (2017)

HepaCAM inhibits the malignant behavior of castration-resistant prostate cancer cells by downregulating Notch signaling and PF-3084014 (a γ-secretase inhibitor) partly reverses the resistance of refractory prostate cancer to docetaxel and enzalutamide in vitro
por: Du, Zhongbo, et al.
Publicado: (2018)

The targeted inhibition of prostate cancer by iron-based nanoparticles based on bioinformatics
por: Xiao, Feng, et al.
Publicado: (2020)

CircPLCE1 facilitates the malignant progression of colorectal cancer by repressing the SRSF2‐dependent PLCE1 pre‐RNA splicing
por: Chen, Zhilei, et al.
Publicado: (2021)

Simvastatin delays castration-resistant prostate cancer metastasis and androgen receptor antagonist resistance by regulating the expression of caveolin-1
por: Gao, Yingying, et al.
Publicado: (2019)

Systematic Evaluation for the Influences of the SOX17/Notch Receptor Family Members on Reversing Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cells
por: Du, Zhongbo, et al.
Publicado: (2021)

Inhibitor 9 Combined With Androgen Deprivation Therapy or Chemotherapy Delays the Malignant Behavior of Castration-Resistant Prostate Cancer Through K-Ras/PLCε/PKCε Signaling Pathway
por: Liu, Jiayu, et al.
Publicado: (2020)

Phospholipase Cɛ Regulates Prostate Cancer Lipid Metabolism and Proliferation by Targeting AMP-Activated Protein Kinase (AMPK)/Sterol Regulatory Element-Binding Protein 1 (SREBP-1) Signaling Pathway
por: Zheng, Yongbo, et al.
Publicado: (2020)

PLCE1 regulates the migration, proliferation, and differentiation of podocytes
por: Yu, Seyoung, et al.
Publicado: (2020)

Long noncoding RNA HOTAIR regulates the invasion and metastasis of prostate cancer by targeting hepaCAM
por: Li, Ting, et al.
Publicado: (2020)

Kava Components Down-Regulate Expression of AR and AR Splice Variants and Reduce Growth in Patient-Derived Prostate Cancer Xenografts in Mice
por: Li, Xuesen, et al.
Publicado: (2012)

Functional significance of the hepaCAM gene in bladder cancer
por: He, Yunfeng, et al.
Publicado: (2010)

Emerging proteins involved in castration-resistant prostate cancer via the AR-dependent and AR-independent pathways (Review)
por: Feng, Kangle, et al.
Publicado: (2023)

PLCE1 Polymorphism and Upper Gastrointestinal Cancer Risk: A Meta-Analysis
por: Hao, Ning-Bo, et al.
Publicado: (2013)

Impaired Delta Np63 Expression is Associated with Poor Tumor Development in Transitional Cell Carcinoma of the Bladder
por: He, Yunfeng, et al.
Publicado: (2008)

PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population
por: Liang, Ping, et al.
Publicado: (2019)

Antisense oligonucleotide targeting Livin induces apoptosis of human bladder cancer cell via a mechanism involving caspase 3
por: Chuan, Liu, et al.
Publicado: (2010)

Genetic Variants of MICB and PLCE1 and Associations with Non-Severe Dengue
por: Whitehorn, James, et al.
Publicado: (2013)

Low PLCE1 levels are correlated with poor prognosis in hepatocellular carcinoma
por: Cheng, Ya, et al.
Publicado: (2016)

Genetic variants of MICB and PLCE1 and associations with the laboratory features of dengue
por: Whitehorn, James, et al.
Publicado: (2017)

PLCε regulates prostate cancer mitochondrial oxidative metabolism and migration via upregulation of Twist1
por: Fan, Jiaxin, et al.
Publicado: (2019)

Metformin exerts anti-AR-negative prostate cancer activity via AMPK/autophagy signaling pathway
por: Chen, Chunyang, et al.
Publicado: (2021)

In vitro and in vivo studies of pirarubicin-loaded SWNT for the treatment of bladder cancer
por: Chen, Gang, et al.
Publicado: (2012)

Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer
por: Wang, Rong, et al.
Publicado: (2020)

Negative regulation of tumor-infiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway
por: Xia, Yang, et al.
Publicado: (2017)

Clinical significance of the correlation between PLCE 1 and PRKCA in esophageal inflammation and esophageal carcinoma
por: Guo, Yongchen, et al.
Publicado: (2017)

The PLCE1 rs2274223 variant is associated with the risk of laryngeal squamous cell carcinoma
por: Zhang, Yi, et al.
Publicado: (2020)

Genetic Association Studies of MICB and PLCE1 with Severity of Dengue in Indonesian and Taiwanese Populations
por: Faridah, Imaniar Noor, et al.
Publicado: (2023)

Racial Differences in Androgen Receptor (AR) and AR Splice Variants (AR-SVs) Expression in Treatment-Naïve Androgen-Dependent Prostate Cancer
por: Khan, Farhan, et al.
Publicado: (2023)

Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma
por: Cui, Xiao-Bin, et al.
Publicado: (2015)

CircHIPK3 Facilitates the G2/M Transition in Prostate Cancer Cells by Sponging miR-338-3p
por: Liu, Fengchun, et al.
Publicado: (2020)

Celastrol Induces Autophagy by Targeting AR/miR-101 in Prostate Cancer Cells
por: Guo, Jianquan, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_oihjgb9ivjo1d51qdd68qm8ft0