Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells

Berberine (BBR) exhibits diverse bioactivities, including anticancer activity; but its poor druggability limits its applications. In this study, we designed and synthesized a series of 9-O position modified BBR derivatives aiming to improve its cell permeability and anticancer activity, utilizing a...

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Detalles Bibliográficos
Autores principales: Liu, Yi, Zhu, Ke-xin, Cao, Lei, Xie, Zhi-fu, Gu, Min, Lü, Wei, Li, Jing-ya, Nan, Fa-jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468249/
https://www.ncbi.nlm.nih.gov/pubmed/31949294
http://dx.doi.org/10.1038/s41401-019-0346-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468249/
https://www.ncbi.nlm.nih.gov/pubmed/31949294
http://dx.doi.org/10.1038/s41401-019-0346-1

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