Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening

The cAMP-responsive element binding protein (CREB) binding protein (CBP) and adenoviral E1A-binding protein (P300) are two closely related multifunctional transcriptional coactivators. Both proteins contain a bromodomain (BrD) adjacent to the histone acetyl transferase (HAT) catalytic domain, which...

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Detalles Bibliográficos
Autores principales: Zhang, Feng-cai, Sun, Zhong-ya, Liao, Li-ping, Zuo, Yu, Zhang, Dan, Wang, Jun, Chen, Yan-tao, Xiao, Sen-hao, Jiang, Hao, Lu, Tian, Xu, Pan, Yue, Li-yan, Du, Dao-hai, Zhang, Hao, Liu, Chuan-peng, Luo, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468272/
https://www.ncbi.nlm.nih.gov/pubmed/31253937
http://dx.doi.org/10.1038/s41401-019-0256-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468272/
https://www.ncbi.nlm.nih.gov/pubmed/31253937
http://dx.doi.org/10.1038/s41401-019-0256-2

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