Shikonin attenuates hyperhomocysteinemia-induced CD4(+) T cell inflammatory activation and atherosclerosis in ApoE(−/−) mice by metabolic suppression

T cell metabolic activation plays a crucial role in inflammation of atherosclerosis. Shikonin (SKN), a natural naphthoquinone with anti-inflammatory activity, has shown to exert cardioprotective effects, but the effect of SKN on atherosclerosis is unclear. In addition, SKN was found to inhibit glyco...

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Detalles Bibliográficos
Autores principales: Lü, Si-lin, Dang, Guo-hui, Deng, Jia-cheng, Liu, Hui-ying, Liu, Bo, Yang, Juan, Ma, Xiao-long, Miao, Yu-tong, Jiang, Chang-tao, Xu, Qing-bo, Wang, Xian, Feng, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468273/
https://www.ncbi.nlm.nih.gov/pubmed/31607752
http://dx.doi.org/10.1038/s41401-019-0308-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468273/
https://www.ncbi.nlm.nih.gov/pubmed/31607752
http://dx.doi.org/10.1038/s41401-019-0308-7

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