Cargando…

Shikonin attenuates hyperhomocysteinemia-induced CD4(+) T cell inflammatory activation and atherosclerosis in ApoE(−/−) mice by metabolic suppression

T cell metabolic activation plays a crucial role in inflammation of atherosclerosis. Shikonin (SKN), a natural naphthoquinone with anti-inflammatory activity, has shown to exert cardioprotective effects, but the effect of SKN on atherosclerosis is unclear. In addition, SKN was found to inhibit glyco...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lü, Si-lin, Dang, Guo-hui, Deng, Jia-cheng, Liu, Hui-ying, Liu, Bo, Yang, Juan, Ma, Xiao-long, Miao, Yu-tong, Jiang, Chang-tao, Xu, Qing-bo, Wang, Xian, Feng, Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468273/ https://www.ncbi.nlm.nih.gov/pubmed/31607752 http://dx.doi.org/10.1038/s41401-019-0308-7

Ejemplares similares

GSNOR modulates hyperhomocysteinemia-induced T cell activation and atherosclerosis by switching Akt S-nitrosylation to phosphorylation
por: Li, Jing, et al.
Publicado: (2018)

Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis
por: Ma, Xiaolong, et al.
Publicado: (2022)

Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice
por: Wang, Renqing, et al.
Publicado: (2017)

Association of prehypertension and hyperhomocysteinemia with subclinical atherosclerosis in asymptomatic Chinese: a cross-sectional study
por: Liu, Bo, et al.
Publicado: (2018)

Hyperhomocysteinemia, Suppressed Immunity, and Altered Oxidative Metabolism Caused by Pathogenic Microbes in Atherosclerosis and Dementia
por: McCully, Kilmer S.
Publicado: (2017)

Hyperhomocysteinemia independently causes and promotes atherosclerosis in LDL receptor-deficient mice
por: Guo, Hang-Yuan, et al.
Publicado: (2014)

Epigenetic Regulation by microRNAs in Hyperhomocysteinemia-Accelerated Atherosclerosis
por: Griñán, Raquel, et al.
Publicado: (2022)

Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe(−/−) Mice
por: Tang, Yang, et al.
Publicado: (2020)

Effect of Shikonin Against Candida albicans Biofilms
por: Yan, Yu, et al.
Publicado: (2019)

Effects of shikonin on the development of ovarian follicles and female germline stem cells
por: Ma, Shu-Xin, et al.
Publicado: (2021)

Hyperhomocysteinemia Potentiates Hyperglycemia-Induced Inflammatory Monocyte Differentiation and Atherosclerosis
por: Fang, Pu, et al.
Publicado: (2014)

Hyperhomocysteinemia is an independent risk factor of atherosclerosis in patients with metabolic syndrome
por: Piazzolla, Giuseppina, et al.
Publicado: (2019)

Mononuclear cell therapy attenuates atherosclerosis in apoE KO mice
por: Porto, Marcella L, et al.
Publicado: (2011)

Thrombin inhibition by dabigatran attenuates atherosclerosis in ApoE deficient mice
por: Pingel, Simon, et al.
Publicado: (2014)

Thymic Stromal Lymphopoietin Attenuates the Development of Atherosclerosis in ApoE(−/−) Mice
por: Yu, Kunwu, et al.
Publicado: (2013)

Canagliflozin attenuates the progression of atherosclerosis and inflammation process in APOE knockout mice
por: Nasiri-Ansari, Νarjes, et al.
Publicado: (2018)

Shikonin Attenuates Hepatic Steatosis by Enhancing Beta Oxidation and Energy Expenditure via AMPK Activation
por: Gwon, So Young, et al.
Publicado: (2020)

ApoB-Specific CD4(+) T Cells in Mouse and Human Atherosclerosis
por: Marchini, Timoteo, et al.
Publicado: (2021)

Dickkopf‐3 Ablation Attenuates the Development of Atherosclerosis in ApoE‐Deficient Mice
por: Cheng, Wen‐Lin, et al.
Publicado: (2017)

Senescence Inducer Shikonin ROS-Dependently Suppressed Lung Cancer Progression
por: Zheng, Hongming, et al.
Publicado: (2018)

Berberine activates peroxisome proliferator‐activated receptor gamma to increase atherosclerotic plaque stability in Apoe (−/−) mice with hyperhomocysteinemia
por: Li, Hongjun, et al.
Publicado: (2016)

Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation
por: Li, Wenjuan, et al.
Publicado: (2015)

A Deficiency of Herp, an Endoplasmic Reticulum Stress Protein, Suppresses Atherosclerosis in ApoE Knockout Mice by Attenuating Inflammatory Responses
por: Shinozaki, Shohei, et al.
Publicado: (2013)

Hyperhomocysteinemia and Accelerated Aging: The Pathogenic Role of Increased Homocysteine in Atherosclerosis, Osteoporosis, and Neurodegeneration
por: Alkaissi, Hussam, et al.
Publicado: (2023)

Compound K Attenuates the Development of Atherosclerosis in ApoE(−/−) Mice via LXRα Activation
por: Zhou, Li, et al.
Publicado: (2016)

Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147
por: Guo, Na, et al.
Publicado: (2019)

Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE(−/−) mice
por: Peng, Juan, et al.
Publicado: (2016)

Targeting ApoC3 Paradoxically Aggravates Atherosclerosis in Hamsters With Severe Refractory Hypercholesterolemia
por: Xu, Yitong, et al.
Publicado: (2022)

Guanmaitong Granule Attenuates Atherosclerosis by Inhibiting Inflammatory Immune Response in ApoE(−/−) Mice Fed High-Fat Diet
por: Yang, Mengqi, et al.
Publicado: (2022)

Guanxinshutong Alleviates Atherosclerosis by Suppressing Oxidative Stress and Proinflammation in ApoE(−/−) Mice
por: Lu, Yingdong, et al.
Publicado: (2020)

Identification of apoB‐100 Peptide‐Specific CD8+ T Cells in Atherosclerosis
por: Dimayuga, Paul C., et al.
Publicado: (2017)

β-sitosterol inhibits trimethylamine production by regulating the gut microbiota and attenuates atherosclerosis in ApoE(–/–) mice
por: Wu, Weiping, et al.
Publicado: (2022)

The Association between Hyperhomocysteinemia and Thoracoabdominal Aortic Aneurysms in Chinese Population
por: Deng, Jianqing, et al.
Publicado: (2020)

The binding of autotaxin to integrins mediates hyperhomocysteinemia-potentiated platelet activation and thrombosis in mice and humans
por: Han, Lulu, et al.
Publicado: (2021)

The Cholinergic Anti-Inflammatory Pathway Attenuates the Development of Atherosclerosis in Apoe(-/-) Mice through Modulating Macrophage Functions
por: Qian, Zhengjiang, et al.
Publicado: (2021)

Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway
por: Liu, Tong, et al.
Publicado: (2016)

Topoisomerase I Inhibitors, Shikonin and Topotecan, Inhibit Growth and Induce Apoptosis of Glioma Cells and Glioma Stem Cells
por: Zhang, Feng-Lei, et al.
Publicado: (2013)

Folic Acid Attenuates Contrast-Induced Nephropathy in Patients With Hyperhomocysteinemia Undergoing Coronary Catheterization: A Randomized Controlled Trial
por: Peng, Long, et al.
Publicado: (2021)

Silence of TRIB3 Suppresses Atherosclerosis and Stabilizes Plaques in Diabetic ApoE(−/−)/LDL Receptor(−/−) Mice
por: Wang, Zhi-hao, et al.
Publicado: (2012)

Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE(-/-) mice
por: Ma, Chuanrui, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bfsecp833eigbibsf3rr23ikal