Importance of structure-based studies for the design of a novel HIV-1 inhibitor peptide

Based on the structure of an HIV-1 entry inhibitor peptide two stapled- and a retro-enantio peptides have been designed to provide novel prevention interventions against HIV transmission. The three peptides show greater inhibitory potencies in cellular and mucosal tissue pre-clinical models than the...

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Detalles Bibliográficos
Autores principales: Gomara, María J., Perez, Yolanda, Gomez-Gutierrez, Patricia, Herrera, Carolina, Ziprin, Paul, Martinez, Javier P., Meyerhans, Andreas, Perez, Juan J., Haro, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468280/
https://www.ncbi.nlm.nih.gov/pubmed/32879375
http://dx.doi.org/10.1038/s41598-020-71404-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468280/
https://www.ncbi.nlm.nih.gov/pubmed/32879375
http://dx.doi.org/10.1038/s41598-020-71404-0

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