The operational model of allosteric modulation of pharmacological agonism

Proper determination of agonist efficacy is indispensable in the evaluation of agonist selectivity and bias to activation of specific signalling pathways. The operational model (OM) of pharmacological agonism is a useful means for achieving this goal. Allosteric ligands bind to receptors at sites th...

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Detalles Bibliográficos
Autores principales: Jakubík, Jan, Randáková, Alena, Chetverikov, Nikolai, El-Fakahany, Esam E., Doležal, Vladimír
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468285/
https://www.ncbi.nlm.nih.gov/pubmed/32879329
http://dx.doi.org/10.1038/s41598-020-71228-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468285/
https://www.ncbi.nlm.nih.gov/pubmed/32879329
http://dx.doi.org/10.1038/s41598-020-71228-y

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