Discovery and biological evaluation of N-(3-(7-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-4-methyl-2-oxo-2H-pyrimido[4,5-d][1,3]oxazin-1(4H)-yl)phenyl)acrylamide as potent Bruton’s tyrosine kinase inhibitors

Bruton’s tyrosine kinase (BTK) is a key component of the B cell receptor (BCR) signaling pathway and plays a crucial role in B cell malignancies and autoimmune disorders; thus, it is an attractive target for the treatment of B cell related diseases. Here, we evaluated the BTK inhibitory activity of...

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Detalles Bibliográficos
Autores principales: Lai, Meng-zhen, Song, Pei-ran, Dou, Dou, Diao, Yan-yan, Tong, Lin-jiang, Zhang, Tao, Xie, Hua, Li, Hong-lin, Ding, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468319/
https://www.ncbi.nlm.nih.gov/pubmed/31316181
http://dx.doi.org/10.1038/s41401-019-0250-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468319/
https://www.ncbi.nlm.nih.gov/pubmed/31316181
http://dx.doi.org/10.1038/s41401-019-0250-8

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