HA-1H T-Cell Receptor Gene Transfer to Redirect Virus-Specific T Cells for Treatment of Hematological Malignancies After Allogeneic Stem Cell Transplantation: A Phase 1 Clinical Study

Graft-vs.-leukemia (GVL) reactivity after HLA-matched allogeneic stem cell transplantation (alloSCT) is mainly mediated by donor T cells recognizing minor histocompatibility antigens (MiHA). If MiHA are targeted that are exclusively expressed on hematopoietic cells of recipient origin, selective GVL...

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Detalles Bibliográficos
Autores principales: van Balen, Peter, Jedema, Inge, van Loenen, Marleen M., de Boer, Renate, van Egmond, H. M., Hagedoorn, Renate S., Hoogstaten, Conny, Veld, Sabrina A. J., Hageman, Lois, van Liempt, P. A. G., Zwaginga, Jaap-Jan, Meij, Pauline, Veelken, H., Falkenburg, J. H. F., Heemskerk, Mirjam H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468382/
https://www.ncbi.nlm.nih.gov/pubmed/32973756
http://dx.doi.org/10.3389/fimmu.2020.01804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468382/
https://www.ncbi.nlm.nih.gov/pubmed/32973756
http://dx.doi.org/10.3389/fimmu.2020.01804

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