Cargando…
Antagonism of CGRP Signaling by Rimegepant at Two Receptors
The “gepants” are a class of calcitonin gene-related peptide (CGRP) receptor antagonist molecules that have been developed for the prevention and treatment of migraine. Rimegepant is reported to act at the CGRP receptor, has good oral bioavailability, and has had positive clinical trial results. How...
Autores principales: | Pan, Kylie S., Siow, Andrew, Hay, Debbie L., Walker, Christopher S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468408/ https://www.ncbi.nlm.nih.gov/pubmed/32973499 http://dx.doi.org/10.3389/fphar.2020.01240 |
Ejemplares similares
-
Lipidated Calcitonin Gene-Related Peptide (CGRP) Peptide Antagonists Retain CGRP Receptor Activity and Attenuate CGRP Action In Vivo
por: Jamaluddin, Aqfan, et al.
Publicado: (2022) -
Safety of Rimegepant, an Oral CGRP Receptor Antagonist, Plus CGRP Monoclonal Antibodies for Migraine
por: Berman, Gary, et al.
Publicado: (2020) -
Reply to comment on: A second trigeminal CGRP receptor: function and expression of the AMY1 receptor
por: Walker, Christopher S., et al.
Publicado: (2016) -
Efficacy and Safety of Rimegepant for the Acute Treatment of Migraine: Evidence From Randomized Controlled Trials
por: Gao, Bixi, et al.
Publicado: (2020) -
CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons
por: Rees, Tayla A., et al.
Publicado: (2022)