High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis

Cellular senescence is an irreversible cell growth arrest and is associated with aging and age-related diseases. High plasma phosphate (Pi) and deficiency of Klotho contribute to aging and kidney fibrosis, a pathological feature in the aging kidney and chronic kidney disease. This study examined the...

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Detalles Bibliográficos
Autores principales: Maique, Jenny, Flores, Brianna, Shi, Mingjun, Shepard, Sierra, Zhou, Zhiyong, Yan, Shirely, Moe, Orson W., Hu, Ming Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468469/
https://www.ncbi.nlm.nih.gov/pubmed/32973510
http://dx.doi.org/10.3389/fphar.2020.01273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468469/
https://www.ncbi.nlm.nih.gov/pubmed/32973510
http://dx.doi.org/10.3389/fphar.2020.01273

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