Enterovirus Replication Organelles and Inhibitors of Their Formation

Enteroviral replication reorganizes the cellular membrane. Upon infection, viral proteins and hijacked host factors generate unique structures called replication organelles (ROs) to replicate their viral genomes. ROs promote efficient viral genome replication, coordinate the steps of the viral repli...

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Autores principales: Li, Xinhong, Wang, Mingshu, Cheng, Anchun, Wen, Xingjian, Ou, Xumin, Mao, Sai, Gao, Qun, Sun, Di, Jia, Renyong, Yang, Qiao, Wu, Ying, Zhu, Dekang, Zhao, Xinxin, Chen, Shun, Liu, Mafeng, Zhang, Shaqiu, Liu, Yunya, Yu, Yanling, Zhang, Ling, Tian, Bin, Pan, Leichang, Chen, Xiaoyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468505/
https://www.ncbi.nlm.nih.gov/pubmed/32973693
http://dx.doi.org/10.3389/fmicb.2020.01817
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author Li, Xinhong
Wang, Mingshu
Cheng, Anchun
Wen, Xingjian
Ou, Xumin
Mao, Sai
Gao, Qun
Sun, Di
Jia, Renyong
Yang, Qiao
Wu, Ying
Zhu, Dekang
Zhao, Xinxin
Chen, Shun
Liu, Mafeng
Zhang, Shaqiu
Liu, Yunya
Yu, Yanling
Zhang, Ling
Tian, Bin
Pan, Leichang
Chen, Xiaoyue
author_facet Li, Xinhong
Wang, Mingshu
Cheng, Anchun
Wen, Xingjian
Ou, Xumin
Mao, Sai
Gao, Qun
Sun, Di
Jia, Renyong
Yang, Qiao
Wu, Ying
Zhu, Dekang
Zhao, Xinxin
Chen, Shun
Liu, Mafeng
Zhang, Shaqiu
Liu, Yunya
Yu, Yanling
Zhang, Ling
Tian, Bin
Pan, Leichang
Chen, Xiaoyue
author_sort Li, Xinhong
collection PubMed
description Enteroviral replication reorganizes the cellular membrane. Upon infection, viral proteins and hijacked host factors generate unique structures called replication organelles (ROs) to replicate their viral genomes. ROs promote efficient viral genome replication, coordinate the steps of the viral replication cycle, and protect viral RNA from host immune responses. More recent researches have focused on the ultrastructure structures, formation mechanism, and functions in the virus life cycle of ROs. Dynamic model of enterovirus ROs structure is proposed, and the secretory pathway, the autophagy pathway, and lipid metabolism are found to be associated in the formation of ROs. With deeper understanding of ROs, some compounds have been found to show inhibitory effects on viral replication by targeting key proteins in the process of ROs formation. Here, we review the recent findings concerning the role, morphology, biogenesis, formation mechanism, and inhibitors of enterovirus ROs.
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spelling pubmed-74685052020-09-23 Enterovirus Replication Organelles and Inhibitors of Their Formation Li, Xinhong Wang, Mingshu Cheng, Anchun Wen, Xingjian Ou, Xumin Mao, Sai Gao, Qun Sun, Di Jia, Renyong Yang, Qiao Wu, Ying Zhu, Dekang Zhao, Xinxin Chen, Shun Liu, Mafeng Zhang, Shaqiu Liu, Yunya Yu, Yanling Zhang, Ling Tian, Bin Pan, Leichang Chen, Xiaoyue Front Microbiol Microbiology Enteroviral replication reorganizes the cellular membrane. Upon infection, viral proteins and hijacked host factors generate unique structures called replication organelles (ROs) to replicate their viral genomes. ROs promote efficient viral genome replication, coordinate the steps of the viral replication cycle, and protect viral RNA from host immune responses. More recent researches have focused on the ultrastructure structures, formation mechanism, and functions in the virus life cycle of ROs. Dynamic model of enterovirus ROs structure is proposed, and the secretory pathway, the autophagy pathway, and lipid metabolism are found to be associated in the formation of ROs. With deeper understanding of ROs, some compounds have been found to show inhibitory effects on viral replication by targeting key proteins in the process of ROs formation. Here, we review the recent findings concerning the role, morphology, biogenesis, formation mechanism, and inhibitors of enterovirus ROs. Frontiers Media S.A. 2020-08-20 /pmc/articles/PMC7468505/ /pubmed/32973693 http://dx.doi.org/10.3389/fmicb.2020.01817 Text en Copyright © 2020 Li, Wang, Cheng, Wen, Ou, Mao, Gao, Sun, Jia, Yang, Wu, Zhu, Zhao, Chen, Liu, Zhang, Liu, Yu, Zhang, Tian, Pan and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Li, Xinhong
Wang, Mingshu
Cheng, Anchun
Wen, Xingjian
Ou, Xumin
Mao, Sai
Gao, Qun
Sun, Di
Jia, Renyong
Yang, Qiao
Wu, Ying
Zhu, Dekang
Zhao, Xinxin
Chen, Shun
Liu, Mafeng
Zhang, Shaqiu
Liu, Yunya
Yu, Yanling
Zhang, Ling
Tian, Bin
Pan, Leichang
Chen, Xiaoyue
Enterovirus Replication Organelles and Inhibitors of Their Formation
title Enterovirus Replication Organelles and Inhibitors of Their Formation
title_full Enterovirus Replication Organelles and Inhibitors of Their Formation
title_fullStr Enterovirus Replication Organelles and Inhibitors of Their Formation
title_full_unstemmed Enterovirus Replication Organelles and Inhibitors of Their Formation
title_short Enterovirus Replication Organelles and Inhibitors of Their Formation
title_sort enterovirus replication organelles and inhibitors of their formation
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468505/
https://www.ncbi.nlm.nih.gov/pubmed/32973693
http://dx.doi.org/10.3389/fmicb.2020.01817
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