Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4/TRAF6 and PLCγ1-Ca(2+)-NFATc1 signaling pathway

In chronic infectious diseases caused by gram-negative bacteria, such as osteomyelitis, septic arthritis, and periodontitis, osteoclastic activity is enhanced with elevated inflammation, which disturbs the bone homeostasis and results in osteolysis. Lipopolysaccharide (LPS), as a bacteria product, p...

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Detalles Bibliográficos
Autores principales: Zeng, Xiang-zhou, Zhang, Yue-yang, Yang, Qin, Wang, Song, Zou, Bin-hua, Tan, Yan-hui, Zou, Min, Liu, Shu-wen, Li, Xiao-juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468527/
https://www.ncbi.nlm.nih.gov/pubmed/31431733
http://dx.doi.org/10.1038/s41401-019-0289-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468527/
https://www.ncbi.nlm.nih.gov/pubmed/31431733
http://dx.doi.org/10.1038/s41401-019-0289-6

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