Integrative Genomic Analysis Reveals Cancer-Associated Gene Mutations in Chronic Myeloid Leukemia Patients with Resistance or Intolerance to Tyrosine Kinase Inhibitor

INTRODUCTION: While the acquisition of mutations in the ABL1 kinase domain (KD) has been identified as a common mechanism behind tyrosine kinase inhibitor (TKI) resistance, recent genetic studies have revealed that patients with TKI resistance or intolerance frequently harbor one or more genetic alt...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Waner, Xu, Na, Zhou, Xuan, Liu, Liang, Tan, Yaxian, Luo, Jie, Huang, Jixian, Qin, Jiayue, Wang, Juan, Li, Zhimin, Yin, Changxin, Zhou, Lingling, Liu, Xiaoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468532/
https://www.ncbi.nlm.nih.gov/pubmed/32943879
http://dx.doi.org/10.2147/OTT.S257661

Ejemplares similares

Ejemplares similares