Rifampicin induces clathrin-dependent endocytosis and ubiquitin–proteasome degradation of MRP2 via oxidative stress-activated PKC-ERK/JNK/p38 and PI3K signaling pathways in HepG2 cells

It was reported that antituberculosis medicines could induce liver damage via oxidative stress. In this study, we investigated the effects of rifampicin (RFP) on the membrane expression of multidrug resistance-associated protein 2 (MRP2) and the relationship between oxidative stress and RFP-induced...

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Detalles Bibliográficos
Autores principales: Xu, Bao-yan, Tang, Xu-dong, Chen, Jing, Wu, Hong-bo, Chen, Wen-sheng, Chen, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468545/
https://www.ncbi.nlm.nih.gov/pubmed/31316180
http://dx.doi.org/10.1038/s41401-019-0266-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468545/
https://www.ncbi.nlm.nih.gov/pubmed/31316180
http://dx.doi.org/10.1038/s41401-019-0266-0

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