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Endothelin-1 enhances acid-sensing ion channel currents in rat primary sensory neurons

Endothelin-1 (ET-1), an endogenous vasoactive peptide, has been found to play an important role in peripheral pain signaling. Acid-sensing ion channels (ASICs) are key sensors for extracellular protons and contribute to pain caused by tissue acidosis. It remains unclear whether an interaction exists...

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Detalles Bibliográficos
Autores principales: Wu, Lei, Liu, Ting-ting, Jin, Ying, Wei, Shuang, Qiu, Chun-yu, Hu, Wang-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468575/
https://www.ncbi.nlm.nih.gov/pubmed/32107467
http://dx.doi.org/10.1038/s41401-019-0348-z