Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening

Indoleamine 2,3-dioxygenase 1 (IDO1) is emerging as a promising therapeutic target for the treatment of malignant tumors characterized by dysregulated tryptophan metabolism. However, the antitumor efficacy of existing small-molecule IDO1 inhibitors is still unsatisfactory, and the underlying mechani...

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Detalles Bibliográficos
Autores principales: Guo, Wei, Yao, Sheng, Sun, Pu, Yang, Tian-biao, Tang, Chun-ping, Zheng, Ming-yue, Ye, Yang, Meng, Ling-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468576/
https://www.ncbi.nlm.nih.gov/pubmed/31197246
http://dx.doi.org/10.1038/s41401-019-0246-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468576/
https://www.ncbi.nlm.nih.gov/pubmed/31197246
http://dx.doi.org/10.1038/s41401-019-0246-4

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