Cargando…

The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach

Omega-3 polyunsaturated fatty acids (ω-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma...

Descripción completa

Detalles Bibliográficos
Autores principales: Kosek, Vit, Heczkova, Marie, Novak, Frantisek, Meisnerova, Eva, Novákova, Olga, Zelenka, Jaroslav, Bechynska, Kamila, Vrzacova, Nikola, Suttnar, Jiri, Hlavackova, Alzbeta, Dankova, Helena, Bratova, Miriam, Daskova, Nikola, Malinska, Hana, Oliyarnyk, Olena, Wohl, Petr, Bastova, Hana, Hajslova, Jana, Cahova, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468769/
https://www.ncbi.nlm.nih.gov/pubmed/32781598
http://dx.doi.org/10.3390/nu12082351
_version_ 1783578290207850496
author Kosek, Vit
Heczkova, Marie
Novak, Frantisek
Meisnerova, Eva
Novákova, Olga
Zelenka, Jaroslav
Bechynska, Kamila
Vrzacova, Nikola
Suttnar, Jiri
Hlavackova, Alzbeta
Dankova, Helena
Bratova, Miriam
Daskova, Nikola
Malinska, Hana
Oliyarnyk, Olena
Wohl, Petr
Bastova, Hana
Hajslova, Jana
Cahova, Monika
author_facet Kosek, Vit
Heczkova, Marie
Novak, Frantisek
Meisnerova, Eva
Novákova, Olga
Zelenka, Jaroslav
Bechynska, Kamila
Vrzacova, Nikola
Suttnar, Jiri
Hlavackova, Alzbeta
Dankova, Helena
Bratova, Miriam
Daskova, Nikola
Malinska, Hana
Oliyarnyk, Olena
Wohl, Petr
Bastova, Hana
Hajslova, Jana
Cahova, Monika
author_sort Kosek, Vit
collection PubMed
description Omega-3 polyunsaturated fatty acids (ω-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma and erythrocyte lipidome and the propensity of oxidative stress. A cross-sectional comparative study was performed in a cohort of adult patients who were long-term parenterally administered ω-3 PUFAs without (FO/–, n = 9) or with (FO/OO, n = 13) olive oil and healthy age- and sex-matched controls, (n = 30). Lipoperoxidation assessed as plasma and erythrocyte malondialdehyde content was increased in both FO/– and FO/OO groups but protein oxidative stress (protein carbonyls in plasma) and low redox status (GSH/GSSG in erythrocytes) was detected only in the FO/– subcohort. The lipidome of all subjects receiving ω-3 PUFAs was enriched with lipid species containing ω-3 PUFAs (FO/–˃FO/OO). Common characteristic of all PN-dependent patients was high content of fatty acyl-esters of hydroxy-fatty acids (FAHFAs) in plasma while acylcarnitines and ceramides were enriched in erythrocytes. Plasma and erythrocyte concentrations of plasmanyls and plasmalogens (endogenous antioxidants) were decreased in both patient groups with a significantly more pronounced effect in FO/–. We confirmed the protective effect of OO in PN mixtures containing ω-3 PUFAs.
format Online
Article
Text
id pubmed-7468769
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74687692020-09-04 The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach Kosek, Vit Heczkova, Marie Novak, Frantisek Meisnerova, Eva Novákova, Olga Zelenka, Jaroslav Bechynska, Kamila Vrzacova, Nikola Suttnar, Jiri Hlavackova, Alzbeta Dankova, Helena Bratova, Miriam Daskova, Nikola Malinska, Hana Oliyarnyk, Olena Wohl, Petr Bastova, Hana Hajslova, Jana Cahova, Monika Nutrients Article Omega-3 polyunsaturated fatty acids (ω-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma and erythrocyte lipidome and the propensity of oxidative stress. A cross-sectional comparative study was performed in a cohort of adult patients who were long-term parenterally administered ω-3 PUFAs without (FO/–, n = 9) or with (FO/OO, n = 13) olive oil and healthy age- and sex-matched controls, (n = 30). Lipoperoxidation assessed as plasma and erythrocyte malondialdehyde content was increased in both FO/– and FO/OO groups but protein oxidative stress (protein carbonyls in plasma) and low redox status (GSH/GSSG in erythrocytes) was detected only in the FO/– subcohort. The lipidome of all subjects receiving ω-3 PUFAs was enriched with lipid species containing ω-3 PUFAs (FO/–˃FO/OO). Common characteristic of all PN-dependent patients was high content of fatty acyl-esters of hydroxy-fatty acids (FAHFAs) in plasma while acylcarnitines and ceramides were enriched in erythrocytes. Plasma and erythrocyte concentrations of plasmanyls and plasmalogens (endogenous antioxidants) were decreased in both patient groups with a significantly more pronounced effect in FO/–. We confirmed the protective effect of OO in PN mixtures containing ω-3 PUFAs. MDPI 2020-08-06 /pmc/articles/PMC7468769/ /pubmed/32781598 http://dx.doi.org/10.3390/nu12082351 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kosek, Vit
Heczkova, Marie
Novak, Frantisek
Meisnerova, Eva
Novákova, Olga
Zelenka, Jaroslav
Bechynska, Kamila
Vrzacova, Nikola
Suttnar, Jiri
Hlavackova, Alzbeta
Dankova, Helena
Bratova, Miriam
Daskova, Nikola
Malinska, Hana
Oliyarnyk, Olena
Wohl, Petr
Bastova, Hana
Hajslova, Jana
Cahova, Monika
The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach
title The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach
title_full The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach
title_fullStr The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach
title_full_unstemmed The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach
title_short The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach
title_sort ω-3 polyunsaturated fatty acids and oxidative stress in long-term parenteral nutrition dependent adult patients: functional lipidomics approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468769/
https://www.ncbi.nlm.nih.gov/pubmed/32781598
http://dx.doi.org/10.3390/nu12082351
work_keys_str_mv AT kosekvit theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT heczkovamarie theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT novakfrantisek theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT meisnerovaeva theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT novakovaolga theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT zelenkajaroslav theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT bechynskakamila theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT vrzacovanikola theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT suttnarjiri theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT hlavackovaalzbeta theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT dankovahelena theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT bratovamiriam theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT daskovanikola theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT malinskahana theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT oliyarnykolena theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT wohlpetr theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT bastovahana theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT hajslovajana theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT cahovamonika theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT kosekvit ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT heczkovamarie ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT novakfrantisek ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT meisnerovaeva ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT novakovaolga ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT zelenkajaroslav ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT bechynskakamila ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT vrzacovanikola ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT suttnarjiri ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT hlavackovaalzbeta ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT dankovahelena ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT bratovamiriam ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT daskovanikola ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT malinskahana ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT oliyarnykolena ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT wohlpetr ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT bastovahana ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT hajslovajana ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach
AT cahovamonika ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach