Cargando…
The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach
Omega-3 polyunsaturated fatty acids (ω-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma...
Autores principales: | , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468769/ https://www.ncbi.nlm.nih.gov/pubmed/32781598 http://dx.doi.org/10.3390/nu12082351 |
_version_ | 1783578290207850496 |
---|---|
author | Kosek, Vit Heczkova, Marie Novak, Frantisek Meisnerova, Eva Novákova, Olga Zelenka, Jaroslav Bechynska, Kamila Vrzacova, Nikola Suttnar, Jiri Hlavackova, Alzbeta Dankova, Helena Bratova, Miriam Daskova, Nikola Malinska, Hana Oliyarnyk, Olena Wohl, Petr Bastova, Hana Hajslova, Jana Cahova, Monika |
author_facet | Kosek, Vit Heczkova, Marie Novak, Frantisek Meisnerova, Eva Novákova, Olga Zelenka, Jaroslav Bechynska, Kamila Vrzacova, Nikola Suttnar, Jiri Hlavackova, Alzbeta Dankova, Helena Bratova, Miriam Daskova, Nikola Malinska, Hana Oliyarnyk, Olena Wohl, Petr Bastova, Hana Hajslova, Jana Cahova, Monika |
author_sort | Kosek, Vit |
collection | PubMed |
description | Omega-3 polyunsaturated fatty acids (ω-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma and erythrocyte lipidome and the propensity of oxidative stress. A cross-sectional comparative study was performed in a cohort of adult patients who were long-term parenterally administered ω-3 PUFAs without (FO/–, n = 9) or with (FO/OO, n = 13) olive oil and healthy age- and sex-matched controls, (n = 30). Lipoperoxidation assessed as plasma and erythrocyte malondialdehyde content was increased in both FO/– and FO/OO groups but protein oxidative stress (protein carbonyls in plasma) and low redox status (GSH/GSSG in erythrocytes) was detected only in the FO/– subcohort. The lipidome of all subjects receiving ω-3 PUFAs was enriched with lipid species containing ω-3 PUFAs (FO/–˃FO/OO). Common characteristic of all PN-dependent patients was high content of fatty acyl-esters of hydroxy-fatty acids (FAHFAs) in plasma while acylcarnitines and ceramides were enriched in erythrocytes. Plasma and erythrocyte concentrations of plasmanyls and plasmalogens (endogenous antioxidants) were decreased in both patient groups with a significantly more pronounced effect in FO/–. We confirmed the protective effect of OO in PN mixtures containing ω-3 PUFAs. |
format | Online Article Text |
id | pubmed-7468769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74687692020-09-04 The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach Kosek, Vit Heczkova, Marie Novak, Frantisek Meisnerova, Eva Novákova, Olga Zelenka, Jaroslav Bechynska, Kamila Vrzacova, Nikola Suttnar, Jiri Hlavackova, Alzbeta Dankova, Helena Bratova, Miriam Daskova, Nikola Malinska, Hana Oliyarnyk, Olena Wohl, Petr Bastova, Hana Hajslova, Jana Cahova, Monika Nutrients Article Omega-3 polyunsaturated fatty acids (ω-3PUFAs) are introduced into parenteral nutrition (PN) as hepatoprotective but may be susceptible to the lipid peroxidation while olive oil (OO) is declared more peroxidation resistant. We aimed to estimate how the lipid composition of PN mixture affects plasma and erythrocyte lipidome and the propensity of oxidative stress. A cross-sectional comparative study was performed in a cohort of adult patients who were long-term parenterally administered ω-3 PUFAs without (FO/–, n = 9) or with (FO/OO, n = 13) olive oil and healthy age- and sex-matched controls, (n = 30). Lipoperoxidation assessed as plasma and erythrocyte malondialdehyde content was increased in both FO/– and FO/OO groups but protein oxidative stress (protein carbonyls in plasma) and low redox status (GSH/GSSG in erythrocytes) was detected only in the FO/– subcohort. The lipidome of all subjects receiving ω-3 PUFAs was enriched with lipid species containing ω-3 PUFAs (FO/–˃FO/OO). Common characteristic of all PN-dependent patients was high content of fatty acyl-esters of hydroxy-fatty acids (FAHFAs) in plasma while acylcarnitines and ceramides were enriched in erythrocytes. Plasma and erythrocyte concentrations of plasmanyls and plasmalogens (endogenous antioxidants) were decreased in both patient groups with a significantly more pronounced effect in FO/–. We confirmed the protective effect of OO in PN mixtures containing ω-3 PUFAs. MDPI 2020-08-06 /pmc/articles/PMC7468769/ /pubmed/32781598 http://dx.doi.org/10.3390/nu12082351 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kosek, Vit Heczkova, Marie Novak, Frantisek Meisnerova, Eva Novákova, Olga Zelenka, Jaroslav Bechynska, Kamila Vrzacova, Nikola Suttnar, Jiri Hlavackova, Alzbeta Dankova, Helena Bratova, Miriam Daskova, Nikola Malinska, Hana Oliyarnyk, Olena Wohl, Petr Bastova, Hana Hajslova, Jana Cahova, Monika The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach |
title | The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach |
title_full | The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach |
title_fullStr | The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach |
title_full_unstemmed | The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach |
title_short | The ω-3 Polyunsaturated Fatty Acids and Oxidative Stress in Long-Term Parenteral Nutrition Dependent Adult Patients: Functional Lipidomics Approach |
title_sort | ω-3 polyunsaturated fatty acids and oxidative stress in long-term parenteral nutrition dependent adult patients: functional lipidomics approach |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468769/ https://www.ncbi.nlm.nih.gov/pubmed/32781598 http://dx.doi.org/10.3390/nu12082351 |
work_keys_str_mv | AT kosekvit theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT heczkovamarie theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT novakfrantisek theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT meisnerovaeva theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT novakovaolga theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT zelenkajaroslav theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT bechynskakamila theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT vrzacovanikola theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT suttnarjiri theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT hlavackovaalzbeta theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT dankovahelena theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT bratovamiriam theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT daskovanikola theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT malinskahana theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT oliyarnykolena theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT wohlpetr theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT bastovahana theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT hajslovajana theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT cahovamonika theō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT kosekvit ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT heczkovamarie ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT novakfrantisek ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT meisnerovaeva ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT novakovaolga ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT zelenkajaroslav ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT bechynskakamila ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT vrzacovanikola ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT suttnarjiri ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT hlavackovaalzbeta ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT dankovahelena ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT bratovamiriam ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT daskovanikola ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT malinskahana ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT oliyarnykolena ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT wohlpetr ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT bastovahana ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT hajslovajana ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach AT cahovamonika ō3polyunsaturatedfattyacidsandoxidativestressinlongtermparenteralnutritiondependentadultpatientsfunctionallipidomicsapproach |