Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage

Insulin resistance leads to excessive endothelial cell (EC) superoxide generation and accelerated atherosclerosis. The principal source of superoxide from the insulin-resistant endothelium is the Nox2 isoform of NADPH oxidase. Here we examine the therapeutic potential of Nox2 inhibition on superoxid...

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Detalles Bibliográficos
Autores principales: Maqbool, Azhar, Watt, Nicole T., Haywood, Natalie, Viswambharan, Hema, Skromna, Anna, Makava, Natalia, Visnagri, Asjad, Shawer, Heba M., Bridge, Katherine, Muminov, Shovkat K., Griffin, Kathryn, Beech, David J., Wheatcroft, Stephen B., Porter, Karen E., Simmons, Katie J., Sukumar, Piruthivi, Shah, Ajay M., Cubbon, Richard M., Kearney, Mark T., Yuldasheva, Nadira Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468885/
https://www.ncbi.nlm.nih.gov/pubmed/32401607
http://dx.doi.org/10.1152/ajpcell.00389.2019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468885/
https://www.ncbi.nlm.nih.gov/pubmed/32401607
http://dx.doi.org/10.1152/ajpcell.00389.2019

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