BDK Deficiency in Cerebral Cortex Neurons Causes Neurological Abnormalities and Affects Endurance Capacity

Branched-chain amino acid (BCAA) catabolism is regulated by its rate-limiting enzyme, branched-chain α-keto acid dehydrogenase (BCKDH), which is negatively regulated by BCKDH kinase (BDK). Loss of BDK function in mice and humans leads to dysregulated BCAA catabolism accompanied by neurological sympt...

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Detalles Bibliográficos
Autores principales: Mizusawa, Anna, Watanabe, Ayako, Yamada, Minori, Kamei, Rina, Shimomura, Yoshiharu, Kitaura, Yasuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469005/
https://www.ncbi.nlm.nih.gov/pubmed/32751134
http://dx.doi.org/10.3390/nu12082267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469005/
https://www.ncbi.nlm.nih.gov/pubmed/32751134
http://dx.doi.org/10.3390/nu12082267

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