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BDK Deficiency in Cerebral Cortex Neurons Causes Neurological Abnormalities and Affects Endurance Capacity

Branched-chain amino acid (BCAA) catabolism is regulated by its rate-limiting enzyme, branched-chain α-keto acid dehydrogenase (BCKDH), which is negatively regulated by BCKDH kinase (BDK). Loss of BDK function in mice and humans leads to dysregulated BCAA catabolism accompanied by neurological sympt...

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Detalles Bibliográficos
Autores principales:	Mizusawa, Anna, Watanabe, Ayako, Yamada, Minori, Kamei, Rina, Shimomura, Yoshiharu, Kitaura, Yasuyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469005/ https://www.ncbi.nlm.nih.gov/pubmed/32751134 http://dx.doi.org/10.3390/nu12082267

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