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Effect of Varying Molecular Weight of Oat β-Glucan Taken just before Eating on Postprandial Glycemic Response in Healthy Humans

To see if the molecular weight (MW) and viscosity of oat β-glucan (OBG) when taken before eating determine its effect on postprandial glycemic responses (PPRG), healthy overnight-fasted subjects (n = 16) were studied on eight separate occasions. Subjects consumed 200 mL water alone (Control) or with...

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Autores principales: Wolever, Thomas M. S., Mattila, Outi, Rosa-Sibakov, Natalia, Tosh, Susan M., Jenkins, Alexandra L., Ezatagha, Adish, Duss, Ruedi, Steinert, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469033/
https://www.ncbi.nlm.nih.gov/pubmed/32751269
http://dx.doi.org/10.3390/nu12082275
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author Wolever, Thomas M. S.
Mattila, Outi
Rosa-Sibakov, Natalia
Tosh, Susan M.
Jenkins, Alexandra L.
Ezatagha, Adish
Duss, Ruedi
Steinert, Robert E.
author_facet Wolever, Thomas M. S.
Mattila, Outi
Rosa-Sibakov, Natalia
Tosh, Susan M.
Jenkins, Alexandra L.
Ezatagha, Adish
Duss, Ruedi
Steinert, Robert E.
author_sort Wolever, Thomas M. S.
collection PubMed
description To see if the molecular weight (MW) and viscosity of oat β-glucan (OBG) when taken before eating determine its effect on postprandial glycemic responses (PPRG), healthy overnight-fasted subjects (n = 16) were studied on eight separate occasions. Subjects consumed 200 mL water alone (Control) or with 4 g OBG varying in MW and viscosity followed, 2–3 min later, by 113 g white-bread. Blood was taken fasting and at 15, 30, 45, 60, 90, and 120 min after starting to eat. None of the OBG treatments differed significantly from the Control for the a-priori primary endpoint of glucose peak-rise or secondary endpoint of incremental area-under-the-curve (iAUC) over 0–120 min. However, significant differences from the Control were seen for glucose iAUC over 0–45 min and time to peak (TTP) glucose. Lower log(MW) and log(viscosity) were associated with higher iAUC 0–45 (p < 0.001) and shorter TTP (p < 0.001). We conclude that when 4 g OBG is taken as a preload, reducing MW does not affect glucose peak rise or iAUC0-120, but rather accelerates the rise in blood glucose and reduces the time it takes glucose to reach the peak. However, this is based on post-hoc calculation of iAUC0-45 and TTP and needs to be confirmed in a subsequent study.
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spelling pubmed-74690332020-09-04 Effect of Varying Molecular Weight of Oat β-Glucan Taken just before Eating on Postprandial Glycemic Response in Healthy Humans Wolever, Thomas M. S. Mattila, Outi Rosa-Sibakov, Natalia Tosh, Susan M. Jenkins, Alexandra L. Ezatagha, Adish Duss, Ruedi Steinert, Robert E. Nutrients Article To see if the molecular weight (MW) and viscosity of oat β-glucan (OBG) when taken before eating determine its effect on postprandial glycemic responses (PPRG), healthy overnight-fasted subjects (n = 16) were studied on eight separate occasions. Subjects consumed 200 mL water alone (Control) or with 4 g OBG varying in MW and viscosity followed, 2–3 min later, by 113 g white-bread. Blood was taken fasting and at 15, 30, 45, 60, 90, and 120 min after starting to eat. None of the OBG treatments differed significantly from the Control for the a-priori primary endpoint of glucose peak-rise or secondary endpoint of incremental area-under-the-curve (iAUC) over 0–120 min. However, significant differences from the Control were seen for glucose iAUC over 0–45 min and time to peak (TTP) glucose. Lower log(MW) and log(viscosity) were associated with higher iAUC 0–45 (p < 0.001) and shorter TTP (p < 0.001). We conclude that when 4 g OBG is taken as a preload, reducing MW does not affect glucose peak rise or iAUC0-120, but rather accelerates the rise in blood glucose and reduces the time it takes glucose to reach the peak. However, this is based on post-hoc calculation of iAUC0-45 and TTP and needs to be confirmed in a subsequent study. MDPI 2020-07-29 /pmc/articles/PMC7469033/ /pubmed/32751269 http://dx.doi.org/10.3390/nu12082275 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wolever, Thomas M. S.
Mattila, Outi
Rosa-Sibakov, Natalia
Tosh, Susan M.
Jenkins, Alexandra L.
Ezatagha, Adish
Duss, Ruedi
Steinert, Robert E.
Effect of Varying Molecular Weight of Oat β-Glucan Taken just before Eating on Postprandial Glycemic Response in Healthy Humans
title Effect of Varying Molecular Weight of Oat β-Glucan Taken just before Eating on Postprandial Glycemic Response in Healthy Humans
title_full Effect of Varying Molecular Weight of Oat β-Glucan Taken just before Eating on Postprandial Glycemic Response in Healthy Humans
title_fullStr Effect of Varying Molecular Weight of Oat β-Glucan Taken just before Eating on Postprandial Glycemic Response in Healthy Humans
title_full_unstemmed Effect of Varying Molecular Weight of Oat β-Glucan Taken just before Eating on Postprandial Glycemic Response in Healthy Humans
title_short Effect of Varying Molecular Weight of Oat β-Glucan Taken just before Eating on Postprandial Glycemic Response in Healthy Humans
title_sort effect of varying molecular weight of oat β-glucan taken just before eating on postprandial glycemic response in healthy humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469033/
https://www.ncbi.nlm.nih.gov/pubmed/32751269
http://dx.doi.org/10.3390/nu12082275
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