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NORRIN plays a context-dependent role in glioblastoma stem cells

We recently reported a novel role of the atypical Wnt ligand, NORRIN, in mediating the proliferation and stemness of glioblastoma stem cells. Mechanistic and functional analysis revealed context-specific phenotypes in which NORRIN can induce opposite effects on the tumor outcome, depending on the un...

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Detalles Bibliográficos
Autores principales: El-Sehemy, Ahmed, Wallace, Valerie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469435/
https://www.ncbi.nlm.nih.gov/pubmed/32944619
http://dx.doi.org/10.1080/23723556.2020.1758540
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author El-Sehemy, Ahmed
Wallace, Valerie A.
author_facet El-Sehemy, Ahmed
Wallace, Valerie A.
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description We recently reported a novel role of the atypical Wnt ligand, NORRIN, in mediating the proliferation and stemness of glioblastoma stem cells. Mechanistic and functional analysis revealed context-specific phenotypes in which NORRIN can induce opposite effects on the tumor outcome, depending on the underlying molecular signature of the tumor cells.
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spelling pubmed-74694352020-09-28 NORRIN plays a context-dependent role in glioblastoma stem cells El-Sehemy, Ahmed Wallace, Valerie A. Mol Cell Oncol Author’s Views We recently reported a novel role of the atypical Wnt ligand, NORRIN, in mediating the proliferation and stemness of glioblastoma stem cells. Mechanistic and functional analysis revealed context-specific phenotypes in which NORRIN can induce opposite effects on the tumor outcome, depending on the underlying molecular signature of the tumor cells. Taylor & Francis 2020-05-14 /pmc/articles/PMC7469435/ /pubmed/32944619 http://dx.doi.org/10.1080/23723556.2020.1758540 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
El-Sehemy, Ahmed
Wallace, Valerie A.
NORRIN plays a context-dependent role in glioblastoma stem cells
title NORRIN plays a context-dependent role in glioblastoma stem cells
title_full NORRIN plays a context-dependent role in glioblastoma stem cells
title_fullStr NORRIN plays a context-dependent role in glioblastoma stem cells
title_full_unstemmed NORRIN plays a context-dependent role in glioblastoma stem cells
title_short NORRIN plays a context-dependent role in glioblastoma stem cells
title_sort norrin plays a context-dependent role in glioblastoma stem cells
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469435/
https://www.ncbi.nlm.nih.gov/pubmed/32944619
http://dx.doi.org/10.1080/23723556.2020.1758540
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