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NORRIN plays a context-dependent role in glioblastoma stem cells
We recently reported a novel role of the atypical Wnt ligand, NORRIN, in mediating the proliferation and stemness of glioblastoma stem cells. Mechanistic and functional analysis revealed context-specific phenotypes in which NORRIN can induce opposite effects on the tumor outcome, depending on the un...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469435/ https://www.ncbi.nlm.nih.gov/pubmed/32944619 http://dx.doi.org/10.1080/23723556.2020.1758540 |
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author | El-Sehemy, Ahmed Wallace, Valerie A. |
author_facet | El-Sehemy, Ahmed Wallace, Valerie A. |
author_sort | El-Sehemy, Ahmed |
collection | PubMed |
description | We recently reported a novel role of the atypical Wnt ligand, NORRIN, in mediating the proliferation and stemness of glioblastoma stem cells. Mechanistic and functional analysis revealed context-specific phenotypes in which NORRIN can induce opposite effects on the tumor outcome, depending on the underlying molecular signature of the tumor cells. |
format | Online Article Text |
id | pubmed-7469435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-74694352020-09-28 NORRIN plays a context-dependent role in glioblastoma stem cells El-Sehemy, Ahmed Wallace, Valerie A. Mol Cell Oncol Author’s Views We recently reported a novel role of the atypical Wnt ligand, NORRIN, in mediating the proliferation and stemness of glioblastoma stem cells. Mechanistic and functional analysis revealed context-specific phenotypes in which NORRIN can induce opposite effects on the tumor outcome, depending on the underlying molecular signature of the tumor cells. Taylor & Francis 2020-05-14 /pmc/articles/PMC7469435/ /pubmed/32944619 http://dx.doi.org/10.1080/23723556.2020.1758540 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Author’s Views El-Sehemy, Ahmed Wallace, Valerie A. NORRIN plays a context-dependent role in glioblastoma stem cells |
title | NORRIN plays a context-dependent role in glioblastoma stem cells |
title_full | NORRIN plays a context-dependent role in glioblastoma stem cells |
title_fullStr | NORRIN plays a context-dependent role in glioblastoma stem cells |
title_full_unstemmed | NORRIN plays a context-dependent role in glioblastoma stem cells |
title_short | NORRIN plays a context-dependent role in glioblastoma stem cells |
title_sort | norrin plays a context-dependent role in glioblastoma stem cells |
topic | Author’s Views |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469435/ https://www.ncbi.nlm.nih.gov/pubmed/32944619 http://dx.doi.org/10.1080/23723556.2020.1758540 |
work_keys_str_mv | AT elsehemyahmed norrinplaysacontextdependentroleinglioblastomastemcells AT wallacevaleriea norrinplaysacontextdependentroleinglioblastomastemcells |