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Targeting tumor vulnerabilities associated with loss of heterozygosity

We show that N-acetyltransferase 2 (NAT2) loss of heterozygosity can be targeted in >4% of colorectal cancers with the use of a small molecule. We identify and describe the effect of a compound that impairs the growth of colorectal tumors with slow NAT2 activity by half when compared to wild-type...

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Detalles Bibliográficos
Autores principales: Rendo, Veronica, Stoimenov, Ivaylo, Sjöblom, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469497/
https://www.ncbi.nlm.nih.gov/pubmed/32944621
http://dx.doi.org/10.1080/23723556.2020.1759390