Targeting tumor vulnerabilities associated with loss of heterozygosity

We show that N-acetyltransferase 2 (NAT2) loss of heterozygosity can be targeted in >4% of colorectal cancers with the use of a small molecule. We identify and describe the effect of a compound that impairs the growth of colorectal tumors with slow NAT2 activity by half when compared to wild-type...

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Autores principales: Rendo, Veronica, Stoimenov, Ivaylo, Sjöblom, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469497/
https://www.ncbi.nlm.nih.gov/pubmed/32944621
http://dx.doi.org/10.1080/23723556.2020.1759390
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author Rendo, Veronica
Stoimenov, Ivaylo
Sjöblom, Tobias
author_facet Rendo, Veronica
Stoimenov, Ivaylo
Sjöblom, Tobias
author_sort Rendo, Veronica
collection PubMed
description We show that N-acetyltransferase 2 (NAT2) loss of heterozygosity can be targeted in >4% of colorectal cancers with the use of a small molecule. We identify and describe the effect of a compound that impairs the growth of colorectal tumors with slow NAT2 activity by half when compared to wild-type.
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spelling pubmed-74694972020-09-28 Targeting tumor vulnerabilities associated with loss of heterozygosity Rendo, Veronica Stoimenov, Ivaylo Sjöblom, Tobias Mol Cell Oncol Author's Views We show that N-acetyltransferase 2 (NAT2) loss of heterozygosity can be targeted in >4% of colorectal cancers with the use of a small molecule. We identify and describe the effect of a compound that impairs the growth of colorectal tumors with slow NAT2 activity by half when compared to wild-type. Taylor & Francis 2020-05-13 /pmc/articles/PMC7469497/ /pubmed/32944621 http://dx.doi.org/10.1080/23723556.2020.1759390 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author's Views
Rendo, Veronica
Stoimenov, Ivaylo
Sjöblom, Tobias
Targeting tumor vulnerabilities associated with loss of heterozygosity
title Targeting tumor vulnerabilities associated with loss of heterozygosity
title_full Targeting tumor vulnerabilities associated with loss of heterozygosity
title_fullStr Targeting tumor vulnerabilities associated with loss of heterozygosity
title_full_unstemmed Targeting tumor vulnerabilities associated with loss of heterozygosity
title_short Targeting tumor vulnerabilities associated with loss of heterozygosity
title_sort targeting tumor vulnerabilities associated with loss of heterozygosity
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469497/
https://www.ncbi.nlm.nih.gov/pubmed/32944621
http://dx.doi.org/10.1080/23723556.2020.1759390
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