Ser(784) phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response

Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser(784) phosphorylation specifically increases VCP function for the DNA damage...

Descripción completa

Detalles Bibliográficos
Autor principal: Shao, Jieya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469644/
https://www.ncbi.nlm.nih.gov/pubmed/32944647
http://dx.doi.org/10.1080/23723556.2020.1796179
_version_ 1783578442542874624
author Shao, Jieya
author_facet Shao, Jieya
author_sort Shao, Jieya
collection PubMed
description Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser(784) phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients.
format Online
Article
Text
id pubmed-7469644
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-74696442020-09-28 Ser(784) phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response Shao, Jieya Mol Cell Oncol Author's Views Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser(784) phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients. Taylor & Francis 2020-08-12 /pmc/articles/PMC7469644/ /pubmed/32944647 http://dx.doi.org/10.1080/23723556.2020.1796179 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Shao, Jieya
Ser(784) phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response
title Ser(784) phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response
title_full Ser(784) phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response
title_fullStr Ser(784) phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response
title_full_unstemmed Ser(784) phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response
title_short Ser(784) phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response
title_sort ser(784) phosphorylation: a clinically relevant enhancer of vcp function in the dna damage response
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469644/
https://www.ncbi.nlm.nih.gov/pubmed/32944647
http://dx.doi.org/10.1080/23723556.2020.1796179
work_keys_str_mv AT shaojieya ser784phosphorylationaclinicallyrelevantenhancerofvcpfunctioninthednadamageresponse

Ejemplares similares