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Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development
We recently developed a Brca1 coiled-coil mutant mouse model (Brca1(CC)). Brca1(CC/CC) results in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia. Brca1(CC/CC) cells lacked Rad51 foci and were PARP inhibitor sensitive. Strikingly, inter-cross...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469674/ https://www.ncbi.nlm.nih.gov/pubmed/32944641 http://dx.doi.org/10.1080/23723556.2020.1786345 |