Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development

We recently developed a Brca1 coiled-coil mutant mouse model (Brca1(CC)). Brca1(CC/CC) results in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia. Brca1(CC/CC) cells lacked Rad51 foci and were PARP inhibitor sensitive. Strikingly, inter-cross...

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Autores principales: Krais, J. J., Johnson, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469674/
https://www.ncbi.nlm.nih.gov/pubmed/32944641
http://dx.doi.org/10.1080/23723556.2020.1786345
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author Krais, J. J.
Johnson, N.
author_facet Krais, J. J.
Johnson, N.
author_sort Krais, J. J.
collection PubMed
description We recently developed a Brca1 coiled-coil mutant mouse model (Brca1(CC)). Brca1(CC/CC) results in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia. Brca1(CC/CC) cells lacked Rad51 foci and were PARP inhibitor sensitive. Strikingly, inter-crossing with Brca1(Δ11) generated Brca1(CC/Δ11) mice that were developmentally normal.
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spelling pubmed-74696742020-09-28 Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development Krais, J. J. Johnson, N. Mol Cell Oncol Author's Views We recently developed a Brca1 coiled-coil mutant mouse model (Brca1(CC)). Brca1(CC/CC) results in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia. Brca1(CC/CC) cells lacked Rad51 foci and were PARP inhibitor sensitive. Strikingly, inter-crossing with Brca1(Δ11) generated Brca1(CC/Δ11) mice that were developmentally normal. Taylor & Francis 2020-07-20 /pmc/articles/PMC7469674/ /pubmed/32944641 http://dx.doi.org/10.1080/23723556.2020.1786345 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Krais, J. J.
Johnson, N.
Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development
title Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development
title_full Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development
title_fullStr Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development
title_full_unstemmed Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development
title_short Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development
title_sort brca1 mutations in the coiled-coil domain impede rad51 loading on dna and mouse development
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469674/
https://www.ncbi.nlm.nih.gov/pubmed/32944641
http://dx.doi.org/10.1080/23723556.2020.1786345
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