Substituted 4,5′-Bithiazoles as Catalytic Inhibitors of Human DNA Topoisomerase IIα

[Image: see text] Human type II topoisomerases, molecular motors that alter the DNA topology, are a major target of modern chemotherapy. Groups of catalytic inhibitors represent a new approach to overcome the known limitations of topoisomerase II poisons such as cardiotoxicity and induction of secon...

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Detalles Bibliográficos
Autores principales: Bergant Loboda, Kaja, Janežič, Matej, Štampar, Martina, Žegura, Bojana, Filipič, Metka, Perdih, Andrej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469689/
https://www.ncbi.nlm.nih.gov/pubmed/32484690
http://dx.doi.org/10.1021/acs.jcim.0c00202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469689/
https://www.ncbi.nlm.nih.gov/pubmed/32484690
http://dx.doi.org/10.1021/acs.jcim.0c00202

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