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Synthetic lethality strategies: Beyond BRCA1/2 mutations in pancreatic cancer
Cancer cells are often characterized by abnormalities in DNA damage response including defects in cell cycle checkpoints and/or DNA repair. Synthetic lethality between DNA damage repair (DDR) pathways has provided a paradigm for cancer therapy by targeting DDR. The successful example is that cancer...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469842/ https://www.ncbi.nlm.nih.gov/pubmed/32639661 http://dx.doi.org/10.1111/cas.14565 |