Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance

Angiopoietin-like protein (ANGPTL)3 regulates plasma lipids by inhibiting LPL and endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical LDLR-mediated pathway and represents a promising therapeutic approach for individuals with homozygous familial hypercholesterole...

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Detalles Bibliográficos
Autores principales: Adam, Rene C., Mintah, Ivory J., Alexa-Braun, Corey A., Shihanian, Lisa M., Lee, Joseph S., Banerjee, Poulabi, Hamon, Sara C., Kim, Hye In, Cohen, Jonathan C., Hobbs, Helen H., Van Hout, Cristopher, Gromada, Jesper, Murphy, Andrew J., Yancopoulos, George D., Sleeman, Mark W., Gusarova, Viktoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469887/
https://www.ncbi.nlm.nih.gov/pubmed/32646941
http://dx.doi.org/10.1194/jlr.RA120000888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469887/
https://www.ncbi.nlm.nih.gov/pubmed/32646941
http://dx.doi.org/10.1194/jlr.RA120000888

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