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Synthesis and evaluation of a large library of nitroxoline derivatives as pancreatic cancer antiproliferative agents

Pancreatic cancer (PC) is one of the deadliest carcinomas and in most cases, which are diagnosed with locally advanced or metastatic disease, current therapeutic options are highly unsatisfactory. Based on the anti-proliferative effects shown by nitroxoline, an old urinary antibacterial agent, we ex...

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Detalles Bibliográficos
Autores principales: Veschi, Serena, Carradori, Simone, De Lellis, Laura, Florio, Rosalba, Brocco, Davide, Secci, Daniela, Guglielmi, Paolo, Spano, Mattia, Sobolev, Anatoly P., Cama, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470072/
https://www.ncbi.nlm.nih.gov/pubmed/32588672
http://dx.doi.org/10.1080/14756366.2020.1780228