Cargando…

Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison

In this study, some benzimidazole-oxadiazole derivatives were synthesised and tested for their in vitro anticancer activities on five cancer cell lines, including HeLa, MCF7, A549, HepG2 and C6. Their structures were elucidated by IR, (1)H-NMR, (13)C-NMR, 2 D-NMR and HRMS spectroscopic methods. Amon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Acar Çevik, Ulviye, Sağlık, Begüm Nurpelin, Osmaniye, Derya, Levent, Serkan, Kaya Çavuşoğlu, Betül, Karaduman, Abdullah Burak, Atlı Eklioğlu, Özlem, Özkay, Yusuf, Kaplancıklı, Zafer Asım
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470102/ https://www.ncbi.nlm.nih.gov/pubmed/32811204 http://dx.doi.org/10.1080/14756366.2020.1806831

Ejemplares similares

Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds
por: Karaburun, Ahmet Çağrı, et al.
Publicado: (2019)

Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
por: Levent, Serkan, et al.
Publicado: (2017)

Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
por: Acar Cevik, Ulviye, et al.
Publicado: (2019)

Synthesis and Anticandidal Activity Evaluation of New Benzimidazole-Thiazole Derivatives
por: Kaplancıklı, Zafer Asım, et al.
Publicado: (2017)

Synthesis, Docking Studies and Biological Activity of New Benzimidazole- Triazolothiadiazine Derivatives as Aromatase Inhibitor
por: Acar Çevik, Ulviye, et al.
Publicado: (2020)

Synthesis, in vitro enzyme activity and molecular docking studies of new benzylamine-sulfonamide derivatives as selective MAO-B inhibitors
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2020)

Synthesis and Anticandidal Activity of New Imidazole-Chalcones
por: Osmaniye, Derya, et al.
Publicado: (2018)

Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents
por: Çavuşoğlu, Betül Kaya, et al.
Publicado: (2017)

Design, Synthesis, and Structure–Activity Relationships of Thiazole Analogs as Anticholinesterase Agents for Alzheimer’s Disease
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2020)

Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
por: Karaburun, Ahmet Çağrı, et al.
Publicado: (2018)

Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
por: Ilgın, Sinem, et al.
Publicado: (2017)

Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
por: Osmaniye, Derya, et al.
Publicado: (2019)

Design, Synthesis, In Vitro and In Silico Studies of New Thiazolylhydrazine-Piperazine Derivatives as Selective MAO-A Inhibitors
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2020)

Design, synthesis, and evaluation of novel 2-phenylpropionic acid derivatives as dual COX inhibitory-antibacterial agents
por: Karaca Gençer, Hülya, et al.
Publicado: (2017)

Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2022)

Novel Thiosemicarbazone Derivatives: In Vitro and In Silico Evaluation as Potential MAO-B Inhibitors
por: Osmaniye, Derya, et al.
Publicado: (2021)

Synthesis and Anticancer Activities of Pyrazole–Thiadiazole-Based EGFR Inhibitors
por: Kurban, Berkant, et al.
Publicado: (2023)

Design, Synthesis, and Evaluation of Novel 2H-Benzo[b][1,4]thiazin-3(4H)-one Derivatives as New Acetylcholinesterase Inhibitors
por: Haji Ali, Sazan, et al.
Publicado: (2022)

Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
por: Can, Nafiz Öncü, et al.
Publicado: (2017)

New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation
por: Karaca Gençer, Hülya, et al.
Publicado: (2017)

Synthesis, Antifungal Activities, Molecular Docking and Molecular Dynamic Studies of Novel Quinoxaline-Triazole Compounds
por: Osmaniye, Derya, et al.
Publicado: (2023)

Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
por: Can, Nafiz Öncü, et al.
Publicado: (2017)

Design, Synthesis, and Biological Evaluation Studies of Novel Naphthalene-Chalcone Hybrids As Antimicrobial, Anticandidal, Anticancer, and VEGFR-2 Inhibitors
por: Osmaniye, Derya, et al.
Publicado: (2023)

Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
por: Kaya, Betül, et al.
Publicado: (2017)

Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
por: Osmaniye, Derya, et al.
Publicado: (2018)

Synthesis of novel benzothiazole derivatives and investigation of their enzyme inhibitory effects against Alzheimer's disease
por: Karaca, Şevval, et al.
Publicado: (2022)

Design, Synthesis, and Molecular Modeling Studies of a Novel Benzimidazole as an Aromatase Inhibitor
por: Çevik, Ulviye Acar, et al.
Publicado: (2022)

Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates
por: Çevik, Ulviye Acar, et al.
Publicado: (2017)

Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer’s Disease
por: Hussein, Weiam, et al.
Publicado: (2018)

Synthesis and Molecular Docking of New N-Acyl Hydrazones-Benzimidazole as hCA I and II Inhibitors
por: Küçükoğlu, Kaan, et al.
Publicado: (2023)

Synthesis of Benzimidazole-1,2,4-triazole Derivatives as Potential Antifungal Agents Targeting 14α-Demethylase
por: Güzel, Emir, et al.
Publicado: (2023)

Synthesis, Molecular Docking, Dynamics, Quantum-Chemical Computation, and Antimicrobial Activity Studies of Some New Benzimidazole–Thiadiazole Hybrids
por: Celik, Ismail, et al.
Publicado: (2022)

Investigation of Novel Quinoline–Thiazole Derivatives as Antimicrobial Agents: In Vitro and In Silico Approaches
por: Evren, Asaf Evrim, et al.
Publicado: (2022)

Synthesis of Novel Benzazole Derivatives and Evaluation of Their Antidepressant-Like Activities with Possible Underlying Mechanisms
por: Tokgöz, Gamze, et al.
Publicado: (2018)

Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Antinociceptive Agents
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2016)

Synthesis of Some Oxadiazole Derivatives as New Anticandidal Agents
por: Kaplancikli, Zafer Asim
Publicado: (2011)

Functional Aromatic Poly(1,3,4-Oxadiazole-Ether)s with Benzimidazole Pendants: Synthesis, Thermal and Dielectric Studies
por: Ganesh, Shimoga D., et al.
Publicado: (2014)

Synthesis and Antidepressant Activity Profile of Some Novel Benzothiazole Derivatives
por: Demir Özkay, Ümide, et al.
Publicado: (2017)

Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives
por: Glomb, Teresa, et al.
Publicado: (2021)

Chalcone/1,3,4-Oxadiazole/Benzimidazole hybrids as novel anti-proliferative agents inducing apoptosis and inhibiting EGFR & BRAFV(600E)
por: Hagar, Fatma Fouad, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2udh27o0n5odq6ssnm8hfucbnt