Design, synthesis and biological evaluation of edaravone derivatives bearing the N-benzyl pyridinium moiety as multifunctional anti-Alzheimer’s agents

A series of multi-target directed edaravone derivatives bearing N-benzyl pyridinium moieties were designed and synthesised. Edaravone is a potent antioxidant with significant neuroprotective effects and N-benzyl pyridinium has previously exhibited positive results as part of a dual-site binding, per...

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Detalles Bibliográficos
Autores principales: Zondagh, Luke S., Malan, Sarel F., Joubert, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470113/
https://www.ncbi.nlm.nih.gov/pubmed/32779503
http://dx.doi.org/10.1080/14756366.2020.1801673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470113/
https://www.ncbi.nlm.nih.gov/pubmed/32779503
http://dx.doi.org/10.1080/14756366.2020.1801673

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