Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor

Metachromatic leukodystrophy (MLD) is a rare genetic disease characterised by a dysfunction of the enzyme arylsulphatase A leading to the lysosomal accumulation of cerebroside sulphate (sulphatide) causing subsequent demyelination in patients. The enzyme galactosylceramide (cerebroside) sulphotransf...

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Detalles Bibliográficos
Autores principales: Li, Wenjin, Guillaume, Joren, Baqi, Younis, Wachsmann, Isabell, Gieselmann, Volkmar, Van Calenbergh, Serge, Müller, Christa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470129/
https://www.ncbi.nlm.nih.gov/pubmed/32657203
http://dx.doi.org/10.1080/14756366.2020.1791841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470129/
https://www.ncbi.nlm.nih.gov/pubmed/32657203
http://dx.doi.org/10.1080/14756366.2020.1791841

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