Novel heterocyclic hybrids of pyrazole targeting dihydrofolate reductase: design, biological evaluation and in silico studies

A novel series of pyrazole analogues including hydrazones, pyrazolo[4,3-c]-pyridazines, pyrazolo[3,4-e][1,2,4]triazine and pyrazolo[3,4-d][1,2,3]triazoles was designed, synthesised and screened for their in vitro antimicrobial and DHFR inhibition activity. Compounds bearing benzenesulphonamide moiet...

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Detalles Bibliográficos
Autores principales: Othman, Ismail M. M., Gad-Elkareem, Mohamed A. M., Amr, Abd El-Galil E., Al-Omar, Mohamed A., Nossier, Eman S., Elsayed, Elsayed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470138/
https://www.ncbi.nlm.nih.gov/pubmed/32668994
http://dx.doi.org/10.1080/14756366.2020.1791842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470138/
https://www.ncbi.nlm.nih.gov/pubmed/32668994
http://dx.doi.org/10.1080/14756366.2020.1791842

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