CRISPR interference-guided modulation of glucose pathways to boost aconitic acid production in Escherichia coli

BACKGROUND: One major mission of microbial breeding is high-level production of desired metabolites. Overproduction of intermediate metabolites in core pathways is challenging as it may impair cell growth and viability. RESULTS: Here we report that aconitic acid, an intermediate metabolite in tricar...

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Detalles Bibliográficos
Autores principales: Li, Qingyang, Zhao, Peng, Yin, Hang, Liu, Zhaonan, Zhao, Haifeng, Tian, Pingfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470443/
https://www.ncbi.nlm.nih.gov/pubmed/32883305
http://dx.doi.org/10.1186/s12934-020-01435-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470443/
https://www.ncbi.nlm.nih.gov/pubmed/32883305
http://dx.doi.org/10.1186/s12934-020-01435-9

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