Cargando…
CRISPR interference-guided modulation of glucose pathways to boost aconitic acid production in Escherichia coli
BACKGROUND: One major mission of microbial breeding is high-level production of desired metabolites. Overproduction of intermediate metabolites in core pathways is challenging as it may impair cell growth and viability. RESULTS: Here we report that aconitic acid, an intermediate metabolite in tricar...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470443/ https://www.ncbi.nlm.nih.gov/pubmed/32883305 http://dx.doi.org/10.1186/s12934-020-01435-9 |